Publications by authors named "M Gabriela Costello"
Objective: The present research evaluated the impact of legalizing recreational cannabis among individuals with substance use disorders (SUDs) who may already use cannabis at high rates.
Method: Using an interrupted time series study design, we evaluated the potential impact of legalizing recreational cannabis among individuals seeking treatment for SUD within a hospital-based treatment setting in Guelph, Ontario. We examined 2,925 individuals who entered an inpatient SUD treatment program between April 2017 and December 2021.
Poly(lactide-co-glycolide) (PLGA) is widely used in a variety of long-acting injectables. However, its biodegradable nature creates potential chemical stability challenges during melt extrusion, where PLGA is exposed to elevated temperature (100-140 °C) for several minutes. This study evaluated the thermal stability of three PLGA grades (Resomer® 502, 502H, and 505) with varying molecular weights and chain-ends using a differential scanning calorimeter and twin-screw extruder.
View Article and Find Full Text PDFPeripheral nerve injury (PNI) is characterized by a loss of cellular and axonal integrity, often leading to limited functional recovery and pain. Many PNIs are not amenable to repair with traditional techniques; however, cell therapies, particularly Schwann cells (SCs), offer the promise of neural tissue replacement and functional improvement. Exosomes, which carry cellular signaling molecules, can be secreted by SCs and have shown promise in PNI.
View Article and Find Full Text PDFBackground: Pituitary adenomas rank third among adult intracranial tumors, with an incidence of 3.9- 7.4 cases/per 100,000 annually.
View Article and Find Full Text PDFArticle Synopsis
- Polycystic ovary syndrome (PCOS) is a prevalent health issue that can lead to various reproductive, metabolic, and psychological problems, highlighting the need for a collective approach to establish research priorities in this field.
- A comprehensive process involving international surveys, systematic reviews, and peer validation revealed over 150 key research priorities, focusing on diagnosis, care models, patient information, lifestyle management, and fertility treatments for those with PCOS.
- The resulting clinical research roadmap aims to direct future studies according to the needs and interests of women with PCOS and healthcare providers, addressing this commonly overlooked condition.