Microbial Biofilms in Urinary Tract Infections and Prostatitis: Etiology, Pathogenicity, and Combating strategies.

Urinary tract infections (UTIs) are one of the most important causes of morbidity and health care spending affecting persons of all ages. Bacterial biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and relapses. UTIs associated with microbial biofilms developed on catheters account for a high percentage of all nosocomial infections and are the most common source of Gram-negative bacteremia in hospitalized patients.

Pancreatic beta cell allotransplant in double transgenic mouse model of type 1 diabetes mellitus.

The purpose of this study was to evaluate the therapeutic response to intra-hepatic and intra-portal allotransplant with pancreatic beta cells in double transgenic mice (dTg) with autoimmune diabetes. The results showed an improvement in metabolic and somatic parameters and an increase in survival rate. Histopathology analysis revealed the presence of transplanted islets and the absence of the inflammatory infiltrate 5 days after the procedure and an increase in insulinemia.

[HBsAg carriers--a study performed on a closed collective of 0- to 3-year-old children].

The clinical, functional-histological and mainly the therapeutical aspect in chronic hepatitis, still raises important problems in children's pathology. As the clinical aspect of the chronic liver diseases is variable and less suggestive in the early and even advanced stages in children, the authors followed--for three years--the incidence of biochemical and histological functional disturbances in a closed collectivity of children. Since no specific therapeutical possibilities exist yet, the importance for a better knowledge of epidemiology of post-viral chronic hepatitis is emphasized.

[The etiopathogenesis of chronic hepatitis in children].

The authors study the etiology of chronic hepatitis, with emphasis on the high frequency of the infection with virus B, with a chronization rate of 15-20%. Taking into account the mother fetus, transmission and the increased number of AgHBs chronic carriers, with serious consequences on hepatic affection, the authors insist on the necessity of antiviral vaccination and of the therapy for virus elimination. At the same time, pathogenetic investigations are made for the presence of nonspecific antibodies and antibodies against hepatocytic membrane, elements which prove the permanent character of the hepatic lesions by immune mechanism, induced by the virus B persistence.