Hazelnut oral immunotherapy desensitizes hazelnut but not other tree nut allergies (Nut CRACKER Study).

Background: Data on oral immunotherapy (OIT) for hazelnut allergy is limited and its potential to cross-desensitize for other nuts is unknown.

Objective: To study the efficacy and safety of hazelnut OIT in desensitizing hazelnut and additional tree nuts.

Methods: A prospective observational study of 30 hazelnut allergic patients aged ≥4 years who underwent hazelnut OIT.

Ultrasensitive detection of intact SARS-CoV-2 particles in complex biofluids using microfluidic affinity capture.

Measuring virus in biofluids is complicated by confounding biomolecules coisolated with viral nucleic acids. To address this, we developed an affinity-based microfluidic device for specific capture of intact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our approach used an engineered angiotensin-converting enzyme 2 to capture intact virus from plasma and other complex biofluids.

Fist fighting and increased mortality post-retirement among National Hockey League players.

Objective: Fist fighting among hockey players is thought to have long-term impacts on health. Because of methodological concerns of previous studies, we undertook a retrospective cohort study among retired National Hockey League (NHL) players to estimate rates of all-cause mortality according to the cumulative number of fights in their careers.

Methods: The cohort comprised male hockey players, excluding goaltenders, who played in the NHL from 1967 to 2022.