Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant-Like Behavior.

Human pluripotent stem cells (hPSCs) tend to acquire genetic aberrations upon culture in vitro. Common aberrations are mutations in the tumor suppressor TP53, suspected to confer a growth-advantage to the mutant cells. However, their full impact in the development of malignant features and safety of hPSCs for downstream applications is yet to be elucidated.

Grazing and topography control nutrient pools in low Arctic soils of Southwest Greenland.

Unlabelled: Soil nutrient pools in the dry low Arctic are likely to be released under climatic change and this bioavailability has the potential to increase both terrestrial and aquatic productions. As well as the direct effect of warming, external disturbances such as nutrient deposition and grazing can also drive ecosystem change. This study in the low Arctic Kangerlussuaq area of southwest Greenland compared soil nutrient pools in terms of both topographic position on a catena and by soil depth in two small catchments with contrasting muskox abundance.

Refining lunar impact chronology through high spatial resolution (40)Ar/(39)Ar dating of impact melts.

Quantitative constraints on the ages of melt-forming impact events on the Moon are based primarily on isotope geochronology of returned samples. However, interpreting the results of such studies can often be difficult because the provenance region of any sample returned from the lunar surface may have experienced multiple impact events over the course of billions of years of bombardment. We illustrate this problem with new laser microprobe (40)Ar/(39)Ar data for two Apollo 17 impact melt breccias.

Episodic entrainment of deep primordial mantle material into ocean island basalts.

Chemical differences between mid-ocean ridge basalts (MORBs) and ocean island basalts (OIBs) provide critical evidence that the Earth's mantle is compositionally heterogeneous. MORBs generally exhibit a relatively low and narrow range of (3)He/(4)He ratios on a global scale, whereas OIBs display larger variability in both time and space. The primordial origin of (3)He in OIBs has motivated hypotheses that high (3)He/(4)He ratios are the product of mantle plumes sampling chemically distinct material, but do not account for lower MORB-like (3)He/(4)He ratios in OIBs, nor their observed spatial and temporal variability.

The novel HLA-B*44:02:27 allele, identified by sequencing-based typing of a candidate stem-cell donor.

The HLA-B*44:02:27 allele strongly resembles the HLA-B*44:02:01:01 allele with respect to HLA-C association and haplotype constitution.