Sphingomyelins of Local Fat Depots and Blood Serum as Promising Biomarkers of Cardiovascular Diseases.

Unlabelled: Assessment of the blood lipid spectrum does not always properly reflect local dysfunctional changes in the adipose tissue and prevents identification of all patients at high risk of cardiovascular diseases (CVD). Monitoring of changes in sphingomyelin levels allows to assess and anticipate the development and/or severity of these diseases, as well as to make sphingomyelins new therapeutic targets. was to evaluate the sphingomyelin spectrum of local fat depots and blood serum in connection with clinical and instrumental indicators in patients with coronary artery disease (CAD) and patients with degenerative acquired valvular heart disease (AVHD).

Expression of Ceramide-Metabolizing Enzymes in the Heart Adipose Tissue of Cardiovascular Disease Patients.

Here, we examined the expression of ceramide metabolism enzymes in the subcutaneous adipose tissue (SAT), epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT) of 30 patients with coronary artery disease (CAD) and 30 patients with valvular heart disease (VHD) by means of quantitative polymerase chain reaction and fluorescent Western blotting. The EAT of patients with CAD showed higher expression of the genes responsible for ceramide biosynthesis (, , , , , , and ) and utilization (, ). PVAT was characterized by higher mRNA levels of , , , , and ceramide utilization enzyme ().

[Two-stage treatment of a patient with type I aortic dissection: an open operation combined with endovascular prosthetic repair].

Presented herein are the results of clinical follow up of a patient with type I aortic dissection, subjected to two-stage treatment: the first stage consisted in prosthetic repair of the ascending portion of the aorta and aortic arch, the second stage being endovascular prosthetic repair of the thoracic portion of the aorta with a stent graft. The ostium of the left subclavian artery entrapped into the zone of implantation of the stent graft was occluded by means of the "Amplatzer" device.

[Twelve-year experience of bioprosthesis implantation into infrainguinal arteries].

The study presents the results of 315 infrainguinal artery reconstructions with bioprostheses from bovine internal mammary artery treated with 5% solution of diepoxide (trade name "KemAngioprosthesis"). Primary patency of KemAngioprostheses was 37.5% (n=239) in above-knee and 7.