Publications by authors named "M G Wasniewska"
The pediatric definition of severe obesity (OB) depends on the body mass index (BMI) references. We evaluated different BMI-derived metrics of the World Health Organization (WHO) system to define which cut-off is associated with the highest cardiometabolic risk (CMR); In this multicentric study, data were retrieved for 3727 youths (1937 boys; 2225 children, 1502 adolescents). OB was defined as BMI > 97th percentile (BMI), severe OB was defined as BMI > 99th percentile (BMI), BMI ≥ 120% of the 97th percentile (120% BMI), or BMI Z-score > 3 (WHO tables), or BMI ≥ the International Obesity Task Force (IOTF) value crossing a BMI of 35 kg/m at the age of 18 (IOTF).
View Article and Find Full Text PDFEndocrine disorders in Rett syndrome: a systematic review of the literature.
Front Endocrinol (Lausanne)
November 2024
Background: Rett syndrome (RTT) is an X-linked progressive neurodevelopmental disorder that involves mainly girls and is the second most frequent cause of genetic intellectual disability. RTT leads to neurological regression between 6 and 18 months of life and could be associated with a variable neurological impairment. However, RTT affects not only neurological function but also wide aspects of non-neurological organs.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated Friedewald's and Sampson's formulas for measuring LDL-Cholesterol (LDL-C) in overweight and obese youths aged 5-17 in Italy, involving a total of 1,694 participants from two centers.
- Results indicated that both formulas were highly accurate in estimating LDL-C levels, with comparable sensitivity and specificity, though Friedewald's formula had a higher positive predictive value.
- The authors concluded that calculated LDL-C is a practical tool for screening adolescents, particularly favoring Friedewald's formula due to its simplicity in clinical settings.
Article Synopsis
- Childhood obesity continues to rise globally despite preventive measures, posing significant risks for cardiovascular and metabolic diseases.
- Early onset of obesity increases long-term exposure to health risks, including severe cardiovascular issues that can occur as early as age 40.
- Recommendations include early detection and treatment of related health conditions, promoting weight loss to reduce risks, and monitoring for long-term health management.