Publications by authors named "M G Velarde"
Copper has been widely used as a main component in fungicides due to its versatility and effectivity. However, copper contamination from the environment creates selective pressure for the emergence of copper-tolerant pathogenic fungal strains that may proliferate and further cause damage to important agricultural crops. Although some studies focused on specific cellular mechanisms of copper tolerance, comprehensive genomic data is lacking.
View Article and Find Full Text PDFMolecular determinants of skeletal muscle force loss in response to 5 days of dry immersion in human.
J Cachexia Sarcopenia Muscle
December 2024
Background: Astronauts in Earth's orbit experience microgravity, resulting in a decline of skeletal muscle mass and function. On Earth, models simulating microgravity have shown that the extent of the loss in muscle force is greater than the loss in muscle mass. The reasons behind this disproportionate loss of muscle force are still poorly understood.
View Article and Find Full Text PDFArticle Synopsis
- Sepsis in ICU patients leads to muscle mass loss and decreased function, contributing to long-term disability.
- A study tested whether disabling the myostatin gene, which normally inhibits muscle growth, could help prevent muscle wasting in septic mice, but results showed no benefits.
- Both wild-type and myostatin knock-out mice experienced similar muscle mass and strength loss after sepsis, suggesting that targeting myostatin may not effectively improve outcomes in muscle wasting related to sepsis.
We study the localized states of an extra electron in an anisotropic quasi-two-dimensional system in which the electron-lattice interaction and the anharmonicity of the lattice vibrations are dominant in one direction. This model describes layers of polydiacetylene or other polymer chains, beta sheets of polypeptides, multilevel microstructures of conjugated polymers, and other low-dimensional systems. It is shown that for appropriate parameter values of the system an extra electron can excite a soliton-like mobile wave of the lattice deformation, within which it can get self-trapped.
View Article and Find Full Text PDFBackground: New family planning (FP) product introduction requires understanding the target market and support from stakeholders from across the health sector. We aimed to understand the perspectives of FP providers and other stakeholders on the potential introduction of new subcutaneous (SC) depot medroxyprogesterone acetate (DMPA) injectable contraceptives lasting 4 and 6 months in Nigeria and Uganda.
Methods: Between July 2021 and February 2022, we conducted 48 in-depth interviews (IDIs) and 11 focus group discussions (FGDs) with FP providers and other stakeholders involved with service delivery, program management, and policymaking in Lagos and Abuja in Nigeria and Kampala and Luwero in Uganda.