Publications by authors named "M G Trivella"
In 2019, the International Consortium for Personalised Medicine (ICPerMed) developed a vision on how the use of personalized medicine (PM) approaches will promote "next-generation" medicine in 2030 more firmly centered on the individual's personal characteristics, leading to improved health outcomes within sustainable healthcare systems through research, development, innovation, and implementation for the benefit of patients, citizens, and society. Nevertheless, there are significant hurdles that healthcare professionals, researchers, policy makers, and patients must overcome to implement PM. The ICPerMed aims to provide recommendations to increase stakeholders' awareness on actionable measures to be implemented for the realization of PM.
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- The REDISCOVER consensus conference focused on creating guidelines for the perioperative care of patients with borderline-resectable and locally advanced pancreatic ductal adenocarcinoma (PDAC).
- Using a structured methodology and expert consensus, the conference developed 34 recommendations on various aspects of surgical care, patient selection, and management of pancreatic cancer.
- Despite the low evidence quality for most recommendations, participants highlighted the importance of establishing an international registry to enhance understanding and care for this patient group.
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- Ventricular assist devices (VADs) can help manage end-stage heart failure in children by altering molecular pathways associated with heart function, particularly focusing on microRNAs' (miRNAs) role in the adiponectin (ADPN) system.
- The study involved measuring ADPN levels in pediatric heart failure patients before and after VAD implantation and analyzing heart tissue for miRNA and ADPN system components.
- Results showed that while VAD did not change ADPN levels, it increased the expression of ADPN receptors, with certain miRNAs potentially influencing these changes, indicating miRNAs could be key therapeutic targets for improving heart function in children.