Publications by authors named "M G Sumithra"

Cytomegalovirus (CMV) is a prevalent virus across the world that belongs to the family Herpesviridae but remains dormant in the body unless the immune system is compromised. In addition, when the bacterium is compromised without any health risks, the infection spreads from one person to another person through body fluids, such as saliva, blood, etc. Ganciclovir is an anti- viral medication used in treating viral infections, especially in the treatment of CMV in people with acquired immune deficiency syndrome and immunity at risk.

View Article and Find Full Text PDF

Cancer is characterized by the uncontrolled proliferation and spread of abnormal cells in the body, resulting in the development of tumors or clusters of irregular cells. The factors contributing to cancer are intricate, involving a combination of genetic, environmental, and lifestyle elements. Risk factors for cancer include the use of nicotine, excessive alcohol consumption, exposure to radiation or specific chemicals, and a family history of the disease.

View Article and Find Full Text PDF

Hyperandrogenism, insulin resistance, and estrogen dominance are the prime defining traits of women with polycystic ovarian syndrome which disrupts hormonal, adrenal, or ovarian functions resulting in impaired folliculogenesis and excess androgen production. The purpose of this study is to identify an appropriate bioactive antagonistic ligand from isoquinoline alkaloids [palmatine (PAL), jatrorrhizine (JAT), magnoflorine (MAG) and berberine (BBR)] from stems of . Phytocomponents inhibit/prevent androgenic, estrogenic, and steroidogenic receptors, insulin binding, and resultant hyperandrogenism.

View Article and Find Full Text PDF

Lung segmentation algorithms play a significant role in segmenting theinfected regions in the lungs. This work aims to develop a computationally efficient and robust deep learning model for lung segmentation using chest computed tomography (CT) images with DeepLabV3 + networks for two-class (background and lung field) and four-class (ground-glass opacities, background, consolidation, and lung field). In this work, we investigate the performance of the DeepLabV3 + network with five pretrained networks: Xception, ResNet-18, Inception-ResNet-v2, MobileNet-v2 and ResNet-50.

View Article and Find Full Text PDF

A bacterial or bone infection in the feet causes diabetic foot infection (DFI), which results in reddish skin in the wound and surrounding area. DFI is the most prevalent and dangerous type of diabetic mellitus. It will mainly occur in people with heart disease, renal illness, or eye disease.

View Article and Find Full Text PDF