Publications by authors named "M G Srour"
Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation.
Epilepsia
January 2025
Objective: This study was undertaken to test the following hypotheses in the Atp1a3 mouse (which carries the most common human ATP1A3 (the major subunit of the neuronal Na/K-adenosine triphosphatase [ATPase]) mutation, D801N): sudden unexpected death in epilepsy (SUDEP) occurs during seizures and is due to terminal apneas in some and due to lethal cardiac arrhythmias in others; and Atp1a3 mice have central cardiorespiratory dysregulation and abnormal respiratory drive.
Methods: Comparison was made of littermate wild-type and Atp1a3 groups using (1) simultaneous in vivo video-telemetry recordings of electroencephalogram, electrocardiogram, and breathing; (2) whole-body plethysmography; and (3) hypoglossal nerve recordings.
Results: In Atp1a3 mice, (1) SUDEP consistently occurred during seizures that were more severe than preterminal seizures; (2) seizure clustering occurred in periods preceding SUDEP; (3) slowing of breathing rate (BR) and heart rate was observed preictally before preterminal and terminal seizures; and (4) the sequence during terminal seizures was as follows: bradypnea with bradycardia/cardiac arrhythmias, then terminal apnea, followed by terminal cardiac arrhythmias.
Objective: To compare fall risk scores of hearing aids embedded with inertial measurement units (IMU-HAs) and powered by artificial intelligence (AI) algorithms with scores by trained observers.
Study Design: Prospective, double-blinded, observational study of fall risk scores between trained observers and those of IMU-HAs.
Setting: Tertiary referral center.
Article Synopsis
- - This study researched the effects of omega-3 fatty acids and vitamin D3 supplementation on the nutritional status of newly diagnosed breast cancer patients in Gaza, aiming to tackle cancer-related malnutrition.
- - 88 women were randomly divided into four groups: omega-3, vitamin D, a combination of both, and a control group; the supplements were given for nine weeks while various health measures were taken.
- - Results showed that the combined omega-3 and vitamin D group had significant improvements in nutritional scores, body weight, BMI, blood albumin levels, and protein intake when compared to the other groups.
Introduction: The general-purpose rating scales used by clinical pharmacists to rate their activities have not been extensively studied in specialist care units. This study aims to describe drug-related problems (DRPs) and pharmacist interventions (PIs) in a French hematopoietic cell therapy (HCT) unit and to evaluate the PIs' likely clinical, economic, and organizational impacts.
Methods: We retrospectively assessed all DRPs reported and all PIs issued between December 2018 and December 2021.
Article Synopsis
- * 88 participants were randomly assigned to four groups: omega-3, vitamin D, a combination of both, and a control group, receiving respective supplementations for 9 weeks.
- * Results showed that the combined omega-3 and vitamin D group significantly improved overall health status, functional scores, and reduced fatigue and inflammatory markers when compared to the other groups.