Publications by authors named "M G Seidel"
Introduction: Assessment of circulating tumor DNA (ctDNA) as means to monitor disease activity in translocation-associated tumors has become very popular in clinical practice. However, there are still few studies on its clinical application to date. Our study evaluates the clinical applicability of ctDNA as a biomarker for monitoring minimal residual disease (MRD) in patients with translocation-associated sarcomas.
View Article and Find Full Text PDFComparative efficacy of leniolisib (CDZ173) versus standard of care on rates of respiratory tract infection and serum immunoglobulin M (IgM) levels among individuals with activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS): An externally-controlled study.
Clin Exp Immunol
December 2024
Leniolisib, an oral, targeted phosphoinositide 3-kinase delta (PI3Kδ) inhibitor, was well-tolerated and efficacious versus placebo in treating individuals with activated PI3Kδ syndrome (APDS), an ultra-rare inborn error of immunity (IEI), in a 12-week randomised controlled trial. However, longer-term comparative data versus standard of care are lacking. This externally controlled study compared the long-term effects of leniolisib on annual rate of respiratory tract infections and change in serum immunoglobulin M (IgM) levels versus current standard of care, using data from the leniolisib single-arm open-label extension study 2201E1 (NCT02859727) and the European Society for Immunodeficiencies (ESID) registry.
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- * A study involving 44 adolescents with AN found that food intake and hygiene-related habits significantly decreased from the start of treatment to just before discharge, aligning with a healthy control group.
- * The reduction in food intake habits was linked to weight gain during treatment, suggesting that altering these habits is crucial for successful weight restoration in AN.
Article Synopsis
- The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
- A special data scouting method is utilized to pick out events with low combined momentum in jets.
- This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.
Article Synopsis
- Intense ultrashort laser pulses are crucial in fundamental science, and their high temporal quality can be enhanced using techniques like nonlinear polarization ellipse rotation (NER).
- Post-compression schemes have transformed ultrafast lasers, allowing for the creation of shorter pulses but introducing new pre- and post-pulses that can affect pulse quality.
- By combining NER and post-compression techniques, researchers can effectively shape the output spectrum and improve temporal contrast, even though NER alone cannot suppress the unwanted new pulses generated during compression.