Publications by authors named "M G Pullen"
In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in synaptic strengths. Homeostatic plasticity involves changes in synaptic scaling and regulation of intrinsic excitability. Increases in spontaneous firing and excitability of sensory neurons are evident in some forms of chronic pain in animal models and human patients.
View Article and Find Full Text PDFBackground: Direct common carotid puncture (DCP) is conventionally used as a bailout technique in stroke patients. However, little is known about the relevant anatomy. Our objective was to examine the relationship of the common carotid artery (CCA) to surrounding structures based on different DCP trajectories passing through the artery's center.
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- This study focuses on decentralized methods for recruiting participants in a COVID-19 treatment trial, evaluating their effectiveness and efficiency.
- Five primary recruitment strategies are analyzed: search engine ads, paid ads through national and regional testing companies, electronic health record messaging, and word of mouth.
- The study compares these methods based on patient demographics, recruitment efficiency, and associated costs.
Article Synopsis
- - Metformin shows antiviral properties against SARS-CoV-2 by inhibiting protein translation through the mechanistic target of rapamycin pathway, leading to significant reductions in hospitalizations, emergency visits, and long COVID risk in the COVID-OUT trial.
- - The COVID-OUT trial involved 999 participants and compared metformin, fluvoxamine, and ivermectin; it found a 3.6-fold reduction in viral load with metformin compared to placebo, and reduced rates of detectable viral load and viral rebound.
- - The results indicate that metformin effectively lowers SARS-CoV-2 viral load, potentially explaining its clinical effectiveness, while neither ivermectin nor fluvoxamine showed significant benefits over placebo.
Factor I (FI) is an essential regulator of the complement system. Together with co-factors, FI degrades C3b, which inhibits further complement activation. Genetic mutations in FI are associated with pathological conditions like age-related macular degeneration and atypical hemolytic uremic syndome.
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