[The role of genetic peculiarityes (of organisms) in the resistance to neoplastic processes in August line and Wistar population rats].

The probability of development of the Ehrlich's ascites carcinoma in young August and Wistar rats was investigated. The Ehrlich's carcinoma strain was derived in mice in the N.N.

[Role of genetic peculiarities in resistance of the body to detrimental impacts and protective effects of adaptation].

Review summarizes results of studies performed in two rat strains, August and Wistar, on the role of genetically determined peculiarities of the stress system (system managing the stress response to detrimental impacts) and of stress-limiting systems (systems restricting activation of the stress system and, therefore, detrimental effects of the stress reaction) in the mechanism of resistance to detrimental factors and the effectiveness of adaptation defence against these factors. A concept is substantiated on the dependence of resistance to stress impacts and factors possessing a distinct stress component (emotions, detrimental impacts, myocardial infarction, etc.) on genetically predetermined, innate peculiarities of stress-limiting systems.

Adaptation to intermittent hypoxia restricts nitric oxide overproduction and prevents beta-amyloid toxicity in rat brain.

This study tested the hypothesis that adaptation to intermittent hypoxia (AIH) can prevent overproduction of nitric oxide (NO) in brain and neurodegeneration induced by beta-amyloid (Aβ) toxicity. Rats were injected with a Aβ protein fragment (25-35) into the nucleus basalis magnocellularis. AIH (simulated altitude of 4000 m, 14 days, 4h daily) was produced prior to the Aβ injection.

Prevention of neurodegenerative damage to the brain in rats in experimental Alzheimer's disease by adaptation to hypoxia.

We report here studies addressing the possibility of preventing neurodegenerative changes in the brain using adaptation to periodic hypoxia in rats with experimental Alzheimer's disease induced by administration of the neurotoxic peptide fragment of beta-amyloid (Ab) into the basal magnocellular nucleus. Adaptation to periodic hypoxia was performed in a barochamber (4000 m, 4 h per day, 14 days). The following results were obtained 15 days after administration of Ab.

[Prevention of the brain neurodegeneration in rats with experimental Alzheimer's disease by adaptation to hypoxia].

The study focused on a possibility of preventing brain neurodegeneration by adaptation to intermittent hypoxia (AH) in rats with experimental Alzheimer's disease (AD) modeled by injection of a neurotoxic bert-amyloid peptide fragment (Ab) into n. basalis magnocellularis. AH was produ- ced in an altitude chamber (4.