Publications by authors named "M G Pramateftakis"

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited effective treatments, prompting the need for investigation of novel therapeutic approaches. Eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA) have demonstrated potential anti-inflammatory properties, but their combined effects on UC have not been thoroughly investigated. This study aimed to evaluate the effect of the combined administration of EPA and GLA on clinical and histopathologic features of experimental UC models.

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Background: Rectal prolapse (RP) predominantly affects women over the age of 50 and presents as mucosal, internal, or full thickness prolapse. Strangulated rectal prolapse requires immediate medical intervention, and surgical treatment options include both abdominal and perineal approaches. We aim to present a case series of perineal rectosigmoidectomy performed urgently due to strangulation and argue that Altemeier's procedure is the preferred method for treating strangulated rectal prolapse.

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Laparoscopic adrenalectomy is considered to be the gold standard approach in the field of adrenal surgery. This technique offers advantages of great importance compared to variant laparotomy techniques. Notwithstanding, a technique that needs to be mentioned is the thoracoabdominal approach which facilitates the anatomic exposure of the retroperitoneum, adrenal gland, and great vessels and is strongly recommended for the surgery of large, malignant adrenal tumors.

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Article Synopsis
  • - Growth hormone (GH) potentially enhances the healing of colonic anastomosis in rats after chemotherapy with 5-fluorouracil, bleomycin, and cisplatin, which generally impairs recovery.
  • - In a study involving 80 Wistar rats, those receiving both chemotherapy and GH showed improved collagen deposition, indicated by higher hydroxyproline levels compared to those who only received chemotherapy.
  • - Rats treated with GH and chemotherapy had similar body weights and bursting pressures compared to the control group, although they experienced more adhesions than untreated rats, suggesting GH might help mitigate some adverse effects of chemotherapy on wound healing.
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Article Synopsis
  • Anastomotic leaks are serious complications in gastrointestinal surgeries that significantly affect patients' recovery and quality of life, necessitating more research into effective healing methods.
  • The aim of this study was to review experimental protocols used in high-risk anastomosis in rats, following established systematic review guidelines for credibility.
  • Although 102 relevant studies were identified and analyzed for methods of creating and assessing high-risk anastomosis, there is still a lack of translation of findings to human applications, highlighting the need for more rigorous research in this area.
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