Molecular classification of endometrial cancers (EC) and association with relapse-free survival (RFS) and overall survival (OS) outcomes: Ancillary analysis of GOG-0258.

Purpose: Determine if molecular classification using mismatch repair (MMR) and p53 protein expression predicts recurrence-free survival (RFS) and overall survival (OS) in endometrial cancer (EC) patients treated with chemotherapy and radiation (CRT) versus chemotherapy (CT).

Methods: GOG-0258, a phase III randomized trial (NCT00942357), compared CRT to CT. Immunohistochemistry assessed MMR and p53 status.

Not all uterine carcinosarcomas are created equal: Survival outcomes according to molecular characterization of uterine carcinosarcoma.

Objectives: To assess if ProMisE classifier molecular subtypes are associated with differing survival outcomes in uterine carcinosarcoma (UCS) and compare these outcomes to endometrioid endometrial cancer (EEC) tumors.

Methods: There were 2235 UCS and 6469 EEC tumors using next-generation sequencing of DNA, whole exome sequencing, and RNA. Microsatellite instability (MSI) was tested by IHC and NGS.

Lanthanide-Germanate Adelite, Co(GeO)(OH) ( = La-Sm), with Edge-Sharing Octahedral Chains of Co Ions: Spin Frustration Expected to Form Cycloids.

A new series of 222 adelite-type Co(GeO)(OH) ( = La-Sm) single crystals were grown by a high-temperature, high-pressure hydrothermal method (650 °C and 100 MPa). Single-crystal diffraction refinements yielded chiral one-dimensional (1D) chains of Co along the axis with an average 2.98 Å separation between Co centers in the [CoO(OH)] ribbon chains.

Nurses' Journey Towards Recovery: Describing Suffering During the COVID-19 Pandemic to Present Day.

The nursing profession has been significantly affected by the COVID-19 pandemic, and nurses continue to suffer emotionally and psychologically. The purpose of this study was to describe the experiences of chronic and ongoing occupational psychological trauma nurses have endured during the COVID-19 pandemic to present day. Eight nurses were interviewed between November 2022 and April 2023.

Long-Term Follow-Up and Overall Survival in NRG258, a Randomized Phase III Trial of Chemoradiation Versus Chemotherapy for Locally Advanced Endometrial Carcinoma.

This randomized phase III trial aimed to determine whether treatment with cisplatin and volume-directed radiation followed by carboplatin and paclitaxel for four cycles (chemoradiotherapy [C-RT]) increased recurrence-free survival (RFS) and overall survival (OS) when compared with carboplatin and paclitaxel for six cycles (chemotherapy [CT]) in locally advanced endometrial cancer (UC). Previously reported results showed that C-RT did not improve RFS compared with CT. Here we report the final OS analysis.