Publications by authors named "M G Pomper"
Background: Autopsy and molecular imaging studies suggest altered binding of the α4β2-nicotinic cholinergic receptor (α4β2-nAChR) with cognitive dysfunction in Parkinson's disease (PD).
Objective: To determine the relationship between cortical and hippocampal binding of the α4β2-nAChR with [F]XTRA PET, a high-affinity radiotracer that enables quantification of α4β2-nAChR in these regions, and cognitive function in individuals with PD.
Methods: Individuals with PD (N = 32) and age-similar, controls without PD or dementia (N = 10) completed a cognitive assessment and one 90-min, [F]XTRA PET scan.
Article Synopsis
- Technological innovations in genomics have enabled large sequencing projects and new biological insights in cancer, leading to the rise of liquid biopsy biomarkers.
- Despite progress in precision oncology, challenges remain due to cancer's complexity and variability, impacting effective treatment strategies.
- Advanced imaging technologies are being developed to enhance early detection and treatment options, but there are obstacles to their wider implementation in clinical settings that must be addressed.
Despite the systemic impact of both cancer and the associated immune response, immuno-PET is predominantly centered on assessment of the immune milieu within the tumor microenvironment. The aim of this study was to assess the value of [F]F-AraG PET imaging as a noninvasive method for evaluation of system-wide immune status of patients with non-small cell lung cancer before starting immunotherapy. Eleven patients with advanced non-small cell lung cancer were imaged with [F]F-AraG before starting immunotherapy.
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