Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers-Metabolic Hormones.

The extent of endocrine changes in response to various levels of heat stress and subsequent recovery is not well understood. Two cohorts of 12 Black Angus steers were housed in climate-controlled rooms (CCR) and subjected to three thermal periods: PreChallenge (5 d), Challenge (7 d) and Recovery (5 d). PreChallenge and Recovery provided thermoneutral conditions.

"A torch, a rope, a belly laugh": engaging with the multiple voices of support groups for people living with rare dementia.

Purpose: Rare forms of dementia bring unique difficulties related to age of onset, impact on family commitments, employment and finances, and also bring distinctive needs for support and care. The aim of the present study was to explore and better understand what the concept of support means for people living with different rare dementia (PLwRD) and their care-partners who attend ongoing support groups.

Methods: Representing seven types of rare dementia, source material was collected from 177 PLwRD and care-partners attending in-person support groups, with the goal of developing research-informed group poems, co-constructed by a facilitating poet.

Metagenomics: a new frontier for routine pathology testing of gastrointestinal pathogens.

Background: Accurate and comprehensive identification of enteropathogens, causing infectious gastroenteritis, is essential for optimal patient treatment and effective isolation processes in health care systems. Traditional diagnostic techniques are well established and optimised in low-cost formats. However, thorough testing for a wider range of causal agents is time consuming and remains limited to a subset of pathogenic organisms.

Glycogen synthase GYS1 overactivation contributes to glycogen insolubility and malto-oligoglucan-associated neurodegenerative disease.

Polyglucosans are glycogen molecules with overlong chains, which are hyperphosphorylated in the neurodegenerative Lafora disease (LD). Brain polyglucosan bodies (PBs) cause fatal neurodegenerative diseases including Lafora disease and adult polyglucosan body disease (ABPD), for which treatments, biomarkers, and good understanding of their pathogenesis are currently missing. Mutations in the genes for the phosphatase laforin or the E3 ubiquitin ligase malin can cause LD.

Unraveling Crystal Phase-Driven Activity and Selectivity of WO for Photoelectrochemical Biomass Valorization.

Modulating the crystal phase of a photocatalyst significantly impacts its surface and photochemical properties, allowing for the adjustment of catalytic activity and selectivity, particularly in the electrooxidation reactions of biomass-derived chemicals. Herein, monoclinic and hexagonal phases of WO are employed as photoanodes for the photoelectrochemical conversion of 5-hydroxymethylfurfural (HMF) to 2,5-diformylfuran (DFF). The monoclinic phase demonstrated exceptional performance in photoelectrocatalytic HMF oxidation, achieving remarkable photocurrent densities (1.