Publications by authors named "M G Molloy"
Background: Sleep is critical for healthy brain development and emotional wellbeing, especially during adolescence when sleep, behavior, and neurobiology are rapidly evolving. Theoretical reviews and empirical research have historically focused on how sleep influences mental health through its impact on brain systems. No studies have leveraged data-driven network neuroscience methods to uncover interpretable, brain-wide signatures of sleep duration in adolescence, their socio-environmental origins, or their consequences for cognition and mental health.
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- Polypharmacy, defined as the use of five or more medications, is common in older adults and can lead to serious health issues like cognitive decline, falls, and higher mortality rates.
- A study was conducted on male mice to analyze the effects of both polypharmacy and the strategy of deprescribing (gradually reducing medications) to see how it impacts liver function and related proteins.
- The results showed that polypharmacy caused significant changes in liver protein expression related to immunity and metabolism, while deprescribing had both reversing effects and introduced new changes that could impact geriatric health outcomes.
Adolescence is a period of growth in cognitive performance and functioning. Recently, data-driven measures of brain-age gap, which can index cognitive decline in older populations, have been utilized in adolescent data with mixed findings. Instead of using a data-driven approach, here we assess the maturation status of the brain functional landscape in early adolescence by directly comparing an individual's resting-state functional connectivity (rsFC) to the canonical early-life and adulthood communities.
View Article and Find Full Text PDFObjective: To investigate functional outcomes in children who survived extracorporeal life support at 12 months follow-up post-discharge.
Background: Some patients who require extracorporeal life support acquire significant morbidity during their hospitalisation. The Functional Status Scale is a validated tool that allows quantification of paediatric function.
Background: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood.
Methods: We used a variety of rodent and human experimental model systems to determine whether exercise training can reduce tumor burden in breast cancer and to identify mechanism associated with any exercise training effects on tumor burden.
Results: We show that voluntary wheel running slows tumor development in the mammary specific polyomavirus middle T antigen overexpression (MMTV-PyMT) mouse model of breast cancer but only when mice are not housed alone.