Publications by authors named "M G Migneco"
Article Synopsis
- The study aimed to investigate clinical signs, symptoms, and viral clearance in U.S. adults with adenoviral conjunctivitis (Ad-Cs) within a specific timeframe.
- Patients aged 18 and older were tested for Ad-Cs and followed over three weeks; by day 14, most had no detectable virus, but some symptoms and signs like blurry vision and redness persisted.
- The research highlights that even after the virus is cleared, symptoms may linger, suggesting that relying on clinical signs for determining quarantine length could lead to unnecessarily prolonged isolation.
Significance: This investigation reports the correlation of conjunctival viral titers in adenoviral conjunctivitis with patient-reported symptoms and clinician-graded signs for 21 days of follow-up.
Purpose: Adenoviral conjunctivitis is a highly contagious viral eye infection with significant morbidity and economic impact. This study investigates whether severity of signs and symptoms and time to viral clearance are correlated with conjunctival viral titers at baseline and during 21 days of follow-up.
Clinical Relevance: This study identifies key signs and symptoms of acute conjunctivitis, that when combined with a point-of-care test, can improve clinician accuracy of diagnosing adenoviral conjunctivitis.
Background: Adenoviral conjunctivitis is a common ocular infection with the potential for high economic impact due to widespread outbreaks and subsequent furloughs from work and school. In this report, we describe clinical signs and participant-reported symptoms that most accurately identify polymerase chain reaction (PCR)-confirmed adenoviral conjunctivitis.
Purpose: Accurate diagnosis of adenoviral conjunctivitis (Ad-Cs) is important for timely and appropriate patient management to reduce disease transmission. This study assessed the diagnostic accuracy of a commercially available point-of-care adenovirus immunoassay and determined whether its predictive accuracy is influenced by signal intensities of test result bands.
Methods: Point-of-care immunoassay (AdenoPlus) testing and quantitative polymerase chain reaction (qPCR) testing was performed on conjunctival swab samples obtained from eyes of 186 eligible adult participants with presumed infectious conjunctivitis and symptoms of ≤4 days.