Publications by authors named "M G Mariotti"
Article Synopsis
- Functionalized nanoparticles (NPs) enable targeted delivery of compounds, offering potential for advanced diagnostic and therapeutic applications, particularly against evolving pathogens.
- The study introduces Nano-Immuno-Probes (NIPs) designed to detect and treat Human Herpes Simplex Virus 2, composed of polymeric NPs linked to antibodies targeting the virus.
- NIPs show promising results in size and specificity, with no cytotoxic effects on cell lines, indicating potential for use in delivering therapeutic agents and diagnostics for similar infections.
Article Synopsis
- * Local treatment options like stereotactic ablative radiotherapy (SABR) may help control oligoprogressive disease without modifying systemic treatments, but evidence, mostly from retrospective studies, is limited.
- * The CURB trial indicated no survival benefit for local treatment in breast cancer patients; however, local treatment is still used to delay more toxic systemic therapies, warranting further exploration of who may benefit and potential risks involved.
Although cancer is an age-related disease, how the processes of aging contribute to cancer progression is not well understood. In this study, we uncovered how mouse B cell lymphoma develops as a consequence of a naturally aged system. We show here that this malignancy is associated with an age-associated clonal B cell (ACBC) population that likely originates from age-associated B cells.
View Article and Find Full Text PDFIntroduction: Pain related to injection of propofol during induction of anesthesia decreases from 66.8% without prevention, to 22-31% of cases when lidocaine is associated. Hypnoanalgesia of the hand is currently used for painful procedures in children but has never been evaluated in this indication.
View Article and Find Full Text PDFGravity and mechanical forces cause important alterations in the human skeletal system, as demonstrated by space flights. Innovative animal models like zebrafish embryos and medaka have been introduced to study bone response in ground-based microgravity simulators. We used, for the first time, adult zebrafish in simulated microgravity, with a random positioning machine (RPM) to study bone remodeling in the scales.
View Article and Find Full Text PDF