Biomarkers.

Background: Non-linear statistical analyses on resting-state fMRI (rs-fMRI) using complexity measures have demonstrated progressive decline in complexity from cognitively normal subjects (CN) to patients with Mild Cognitive Impairment (MCI) and patients with Alzheimer's disease (AD). While complexity has been shown to be negatively associated with tau-PET, the association with amyloid or effects of genetic characteristics (APOE4) remains unknown.

Method: From the Alzheimer's Disease Neuroimaging Initiative (ADNI3) we identified participants with tabulated SUVR values for amyloid and tau as well as one resting state fMRI scan for the same visit.

Histopoly: A serious game for teaching histology to 1st year veterinary students.

Histology is a preclinical subject transversal in medical, dental, and veterinary curricula. Classical teaching approaches in histology are often undermined by lower motivation and engagement of students, which may be addressed by innovative learning environments. Herein, we developed a serious game approach and compared it with a classical teaching style.

Septoplasty-mediated improvements in nasal patency and pulmonary function: A prospective study.

Background And Objective: Septoplasty and turbinate reduction surgery (STR) is hypothesized to affect pulmonary function by modifying airway dynamics. This study investigates the impact of STR-mediated improvements in nasal patency on pulmonary function tests (PFTs).

Methods: In a prospective analysis, 37 adult patients undergoing STR were enrolled.

The effects of nickel tungstate nanoparticles (NiWO NPs) on freshwater microalga Raphidocelis subcapitata (Chlorophyceae).

Among the vast array of functional nanoparticles (NPs) under development, nickel tungstate (NiWO) has gained prominence due to its potential applications as a catalyst, sensor, and in the development of supercapacitors. Consequently, new studies on the environmental impact of this material must be conducted to establish a regulatory framework for its management. This work aims to assess the effects of NiWO (NPs) on multiple endpoints (e.

Characterization of patients treated at a rare disease referral service: a descriptive study, 2016-2021.

Objective: To analyze the first referral service for rare diseases accredited by the Brazilian Ministry of Health, focusing on referral from the primary healthcare network through to diagnosis.

Methods: This is a descriptive study with patients treated between 2016 and 2021 at a referral hospital service located in Curitiba, Paraná, Brazil. Clinical and epidemiological data were obtained from medical records, as were the results of genetic tests at the hospital's clinical analysis laboratory.