Publications by authors named "M G Kirienko"
Article Synopsis
- SUVmax is a commonly used but limited parameter in assessing malignant lung nodules, with other metrics like lean body mass-adjusted values potentially offering more reliability.
- A study of 567 patients with suspected lung tumors showed that 91% had primary lung tumors, predominantly adenocarcinomas, yet SUVmax struggled to differentiate between benign and malignant lesions effectively.
- Survival analysis indicated that while SUVmax correlated with factors like overall survival and tumor characteristics, it lacked independent prognostic value, raising doubts about its sole reliance in clinical settings.
Article Synopsis
- Researchers did a review to update how good different types of PET scans are for finding and checking solid cancers (not brain cancers) using special medicines.
- They looked through many studies and found 64 helpful articles that show which types of PET scans work best for various cancers, like prostate and neuroendocrine tumors.
- The review found that some cancers, like esophageal cancer and certain types of lung cancer, don't have enough strong studies to help with diagnosis using PET scans.
The LUTADOSE trial: tumour dosimetry after the first administration predicts progression free survival in gastro-entero-pancreatic neuroendocrine tumours (GEP NETs) patients treated with [Lu]Lu-DOTATATE.
Eur J Nucl Med Mol Imaging
December 2024
Purpose: In Peptide Receptor Radionuclide Therapy (PRRT) with [Lu]Lu-DOTATATE of gastro-entero-pancreatic neuroendocrine tumours (GEP NETs) a question remains open about the potential benefits of personalised dosimetry. This observational prospective study examines the association of individualized dosimetry with progression free survival (PFS) in G1-G2 GEP NETs patients following the standard [Lu]Lu-DOTATATE therapeutic regimen.
Methods: The analysis was conducted on 42 patients administered 4 times, and on 165 lesions.
Medical imaging represents the primary tool for investigating and monitoring several diseases, including cancer. The advances in quantitative image analysis have developed towards the extraction of biomarkers able to support clinical decisions. To produce robust results, multi-center studies are often set up.
View Article and Find Full Text PDFBackground: The value of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) is still unknown. We aimed to test the potential complementary role of PSMA expression and 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG) uptake on PET/CT as biomarkers for TC outcome prediction.
Materials And Methods: From a retrospective cohort of TC patients we selected those fulfilling the following inclusion/exclusion criteria: thyroidectomy in our Institution, available primary tumor tissue PSMA immunostaining, [F]FDG PET/CT and follow-up data.