Publications by authors named "M G Kees"
Article Synopsis
- This study focused on the connection between sepsis and periprosthetic joint infections (PJI) in the hip and knee, examining risk factors and outcomes associated with the condition.
- Among patients with PJI, 40.6% also had sepsis, with higher comorbidity indexes and specific infections like Staphylococcus aureus linked to increased sepsis risk, longer hospital stays, and higher mortality rates.
- The findings highlight the critical need for careful monitoring and prompt treatment for PJI patients to prevent severe complications and improve survival rates.
Acute respiratory distress syndrome (ARDS) is a complex disease pattern in which pathogenesis polymorphonuclear neutrophil granulocytes (PMN) play a key role. In previous experiments, we could show that interaction with collagen III (an important component of pulmonary tissue) is a possible trigger of neutrophil reactive oxygen species (ROS) production. To investigate possible correlations, further elucidate ARDS pathophysiology, and maybe find pharmacological targets, we evaluated PMNs from blood (circulating PMNs: cPMNs) and tracheal secretion (tPMNs) from patients with and without ARDS with regard to function and phenotype.
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- * Five antibiotics were tested in an in vitro model of continuous veno-venous hemodialysis, simulating different patient scenarios to see how drug levels could be adjusted effectively during dialysis.
- * Results indicate that target-controlled dialysis can reliably adjust and maintain antibiotic concentrations at desired therapeutic levels throughout the treatment, suggesting it may improve patient outcomes in critical care settings.
To assess the impact of experimental conditions on free serum concentrations as determined by ultrafiltration and HPLC-DAD analysis in a wide range of antibiotics. Relative centrifugation force (RCF), temperature, pH and buffer were varied and the results compared with the standard protocol (phosphate buffer pH 7.4, 37°C, 1000 × g).
View Article and Find Full Text PDFNational Guard soldiers experience unique reintegration challenges. In addition to managing the consequences of combat-related trauma, they also navigate multiple transitions between military and civilian life. Despite these obstacles, many soldiers report positive outcomes and personal growth due to deployment, a phenomenon most commonly referred to in the literature as posttraumatic growth (PTG).
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