A Personalised Caring Approach at Home-Patients, Relatives and Nurses' Experiences of Specialised Palliative Care: An Integrative Literature Review.

Aim: This study aimed to describe patients, relatives and nurses' experiences of specialised palliative home care.

Design: Integrated literature review.

Methods: The review was performed using the PRISMA 2020 Statement.

Developing ERAF-AI: An Early-stage Research Assessment Framework for Artificial Intelligence.

Today, most research evaluation frameworks are designed to assess mature projects with well-defined data and clearly articulated outcomes. Yet, few, if any, are equipped to evaluate the promise of early-stage research, which is inherently characterized by limited evidence, high uncertainty, and evolving objectives. These early-stage projects require nuanced assessments that can adapt to incomplete information, project maturity, and shifting research questions.

Protein Intake and Its Association With Meal Patterns and Dietary Patterns in a Swedish Population of Older Adults.

Background: Meeting protein intake recommendations is relevant for maintaining muscle mass. This study aimed to describe protein intake and its association with meal patterns and dietary patterns.

Methods: An in-house designed, web-based 4-day record was used in the national dietary survey (in 2010/2011).

Observer- and sequence variability in personalized 4D flow MRI-based cardiovascular models.

Subject-specific parameters in lumped hemodynamic models of the cardiovascular system can be estimated using data from experimental measurements, but the parameter estimation may be hampered by the variability in the input data. In this study, we investigate the influence of inter-sequence, intra-observer, and inter-observer variability in input parameters on estimation of subject-specific model parameters using a previously developed approach for model-based analysis of data from 4D Flow MRI acquisitions and cuff pressure measurements. The investigated parameters describe left ventricular time-varying elastance and aortic compliance.

Neuronal CD59 isoforms IRIS-1 and IRIS-2 as regulators of neurotransmitter release with implications for Alzheimer's disease.

We have previously demonstrated that the intracellular, non-GPI anchored CD59 isoforms IRIS-1 and IRIS-2 (Isoforms Rescuing Insulin Secretion 1 and 2) are necessary for insulin secretion from pancreatic β-cells. While investigating their expression across human tissues, we identified IRIS-1 and IRIS-2 mRNA in the human brain, though their protein expression and function remained unclear. This study shows the presence of both IRIS-1 and 2 proteins in the human brain, specifically in neurons and astrocytes.