Eggshell fractions containing different particle sized affect mineral absorption but not bone mineral retention in growing rats.

The purpose of this study was to compare the calcium (Ca) bioavailability from eggshell fractions containing different particle size to purified CaCO in male growing rats. Mineral absorption, bone mineral concentration, and biomechanical properties were evaluated. Mean Ca absorption of rats fed with eggshell diets amounted to 56.

Supplementation with fiber-rich multimixtures yields a higher dietary concentration and apparent absorption of minerals in rats.

Multimixtures (MMs) are dietary supplements prepared with low-cost ingredients and food by-products that are widely used in various countries to counteract malnutrition. Although MMs have a high content of minerals, they also contain high levels of dietary fiber and associated compounds, which might bind minerals and impair their absorption. In this study, we investigated the hypothesis that the increased dietary fiber content of MMs would impair gastrointestinal mineral absorption due to the metal-binding capacity of dietary fiber.

Effect of wheat bran and flaxseed on cadmium effects and retention in rats.

Dietary fiber can affect cadmium (Cd) absorption and toxicity, but the effect appears to depend on the type of dietary fiber. The aim of the present study was to compare the effect of dietary sources containing distinct amounts of soluble and insoluble fiber on Cd absorption, accumulation and toxicity in growing rats. The absorption of essential macrominerals (Ca, P and Mg) was also evaluated.

Influence of cereal bran supplement on cadmium effects in growing rats.

Strategies to diminish cadmium (Cd) absorption are highly desirable especially where Cd exposure due to environmental contamination is still inevitable. Cd toxicity may be influenced by dietary components, such as fiber and minerals. Multimixtures are low-cost cereal bran supplements used in Brazil and in other countries to counteract malnutrition in low-income populations.

Functional impairment of p16(INK4A) due to CDKN2A p.Gly23Asp missense mutation.

The CDKN2A locus encodes for two distinct tumor suppressor proteins, p16(INK4A) and p14(ARF), involved in cell cycle regulation. CDKN2A germline mutations have been associated with familial predisposition to melanoma and other tumor types. Besides bona-fide pathogenic mutations, many sequence variants have been identified, but their effect is not well known.