Publications by authors named "M G Gopal"
Background: In proximal hypospadias, ventral curvature is invariable and most have penoscrotal transposition, and we observed that the base of the penis (BOP) was located on the inferior aspect of the pubic bones in those, in contrast to the location of the BOP at the anterior end in normal penises. We also observed an unfused bulbospongiosus muscle (BSM) at surgery in those. The aim was to assess the impact of repairing the unfused BSM or transection and straightening of the urethral plate at the first operation on the low BOP.
View Article and Find Full Text PDFNon-standard amino acids (nsAAs) that are L-phenylalanine derivatives with aryl ring functionalization have long been harnessed in natural product synthesis, therapeutic peptide synthesis, and diverse applications of genetic code expansion. Yet, to date these chiral molecules have often been the products of poorly enantioselective and environmentally harsh organic synthesis routes. Here, we reveal the broad specificity of multiple natural pyridoxal 5'-phosphate (PLP)-dependent enzymes, specifically an L-threonine transaldolase, a phenylserine dehydratase, and an aminotransferase, towards substrates that contain aryl side chains with diverse substitutions.
View Article and Find Full Text PDFArticle Synopsis
- The study compares two surgical techniques for treating unstable distal radius fractures: percutaneous fixation using Kirschner wires and open reduction with volar locking plates.
- A systematic review of 14 randomized controlled trials involving 2,226 patients showed that the plating group had better functional outcomes (measured by DASH scores) especially at one-year follow-up, while both techniques had similar radiological results and complication rates.
- The authors emphasize caution in interpreting these results due to variability in the trials and highlight the need for more high-quality studies to establish definitive conclusions across different patient demographics and fracture types.
Context: Despite the Weekly Iron folic acid supplementation (WIFS) program, the prevalence of anaemia among adolescent girls remains high. Phase 1 Indian Council of Medical Research (ICMR) task force study conducted in 2016 in Kallur showed that the IFA provision rate for adolescent girls was 72% but the consumption rate was only 15% in the Kallur area. The present study was done to identify the gaps for the difference between provision and consumption rate of weekly IFA tablets among adolescent girls using the WHO conceptual framework in home-based settings.
View Article and Find Full Text PDFBackground: This update outlines amendments to the CHAMPION2/STRIPES2 cluster randomised trial protocol primarily made due to the COVID-19 pandemic and nationwide lockdown in India in 2020. These amendments were in line with national guidelines for health research during the COVID-19 pandemic.
Methods: We did not change the original trial design, eligibility, and outcomes.