Publications by authors named "M G Ferruzzi"
Article Synopsis
- Maternal diet significantly impacts the profiles of human milk oligosaccharides (HMOs), carotenoids, and polyphenols, but individual variability exists due to non-dietary factors influencing these profiles.
- A pilot study with 16 exclusively breastfeeding women explored the changes in human milk bioactives after following a 4-week meal plan based on the 2020 Dietary Guidelines for Americans, focusing on the relationship with maternal secretor phenotype (FUT2).
- Results showed that only women with the secretor phenotype experienced significant changes in certain HMOs and polyphenol metabolites, indicating a complex relationship between maternal diet and milk composition influenced by genetics.
Article Synopsis
- The study examines the impact of a high-fat diet combined with low-dose streptozotocin on inducing type-2 diabetes in male and female mice to understand sex differences in diabetes development.
- It found that while both sexes gained weight and showed impaired glucose tolerance, only male mice developed significant fasting hyperglycemia and insulin resistance, indicating distinct metabolic effects based on sex.
- The results suggest that existing models for studying type-2 diabetes, particularly the HF diet plus STZ method, are inadequate for females, highlighting the need for new approaches that account for sexual dimorphism in metabolic disease research.
Processed foods have been part of the American diet for decades, with key roles in providing a safe, available, affordable, and nutritious food supply. The USDA Food Guides beginning in 1916 and the US Dietary Guidelines for Americans (DGA) since 1980 have included various types of commonly consumed processed foods (e.g.
View Article and Find Full Text PDFMethod development with high-throughput enhanced matrix removal followed by UHPLC-QqQ-MS/MS for analysis of grape polyphenol metabolites in human urine.
J Chromatogr B Analyt Technol Biomed Life Sci
July 2024
Grape and grape derived products contain many bioactive phenolics which have a variety of impacts on health. Following oral ingestion, the phenolic compounds and their metabolites may be detectable in human urine. However, developing a reliable method for the analysis of phenolic compounds in urine is challenging.
View Article and Find Full Text PDFFoods high in phenolics such as prunes have been shown to exert protective effects on bone mineral density (BMD), but only certain individuals experience these benefits. This analysis of a 12-month randomized controlled trial aimed to identify the relationship among the gut microbiome, immune responses, and bone protective effects of prunes on postmenopausal women. Subjects who consumed 50-100 g prunes daily were divided into responders ( = 20) and non-responders ( = 32) based on percent change in total hip bone mineral density (BMD, ≥1% or ≤-1% change, respectively).
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