The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth.

Precisely timed immune adaptations, observed in the maternal circulation, underpin the notion of an immune clock of human pregnancy that supports its successful progression and completion at delivery. This immune clock is divided into three immunological phases, with the first phase starting at the time of conception and implantation, shifting into the second phase that supports homeostasis and tolerance throughout pregnancy, and culminating in the last phase of labor and parturition. Disruptions of this immune clock are reported in pregnancy complications such as spontaneous preterm birth.

Prevalence of multidrug-resistant bacteria in healthcare and community settings in West Africa: systematic review and meta-analysis.

Background: Multidrug-resistant (MDR) bacteria are a global health threat, notably in low- and middle-income countries. The aim of this review was to estimate the prevalence of multidrug-resistant bacteria in healthcare and community settings in West Africa.

Methods: In accordance with PRISMA guidelines, we searched PubMed, CINAHL, African Index Medicus, and other databases for studies published from 2010 onward.

Left iliac fossa sigmoidectomy with mechanical anastomosis in the management of uncomplicated sigmoid volvulus: an observational study at Principal Hospital of Dakar, Senegal.

Introduction: sigmoidectomy is the definitive treatment of Sigmoid Volvulus (SV). It can be done either by laparotomy or laparoscopy. Our objective was to describe the left iliac fossa sigmoidectomy with mechanical anastomosis recently introduced in our practice, assess our results after 5 years and evaluate its feasibility in our setting.

Study on Microscopic Properties of Molten NaF-AlF-CaF/LiF/KF Using First-Principles Molecular Dynamics.

This study employs first-principles molecular dynamics (FPMD) simulations combined with the Voronoi tessellation method to explore the microstructure, transport properties, electronic properties, and Raman spectra of the NaF-AlF-CaF/LiF/KF systems with varying cryolite ratios, additive types, and concentrations. The results indicate that Na, Ca, Li, and K exist in a free state in the molten salts, while Al forms complex ion groups in the form of [AlF] with F, and free F also exists in the molten salts. In the NaF-AlF-CaF system, the average Al-F distance is slightly shorter than that in the other two systems, while the Al-F coordination number is higher in NaF-AlF-LiF.

Secreted extracellular heat shock protein gp96 and inflammatory cytokines are markers of severe malaria outcome.

Malaria caused by Plasmodium spp., is a major public health issue in sub-Saharan Africa. The fight against malaria has stalled due to increasing resistance to treatments and insecticides.