Development and Validation of a New Cardio-Specific Resting Energy Expenditure Equation for Adults.

Background: This study tested the accuracy of resting energy expenditure (REE) equations among patients who underwent cardiopulmonary bypass and developed/validated a more accurate cardio-specific equation (CSE).

Materials And Methods: Prospective observational cohort of 240 adults (derivation data set, 170 patients; validation data set, 70 patients). REEs were calculated with 6 equations-Penn State 2003a, Penn State 2003b, Ireton-Jones, Swinamer, Faisy, and American College of Chest Physicians-and results were compared with indirect calorimetry (IC).

[Mechanisms of ventilatory disorders in central nervous system lesions].

By taking into account the state of the central nervous system (CNS), anthropometric indices, and the mode of artificial ventilation (AV), the authors used original procedures for estimating the values of respiratory performance and the mechanics of respiration in order to study the specific features of ventilatory disorders in 510 patients (378 males and 132 females) with CNS injuries and diseases, who developed respiratory failure requiring AV for more than 24 hours. Four types of respiratory rhythm regulation, which are of different prognostic value, were identified. These included apneic (100% mortality), hypopneic (44%), normopneic (0%), and hyperpneic (53.

[Kinetic therapy for acute respiratory distress syndrome].

The authors evaluated the clinical and physiological effects of kinetic therapy (KT) in the treatment of acute respiratory distress syndrome (ARDS). Forty-six patients with ARDS underwent successive postural positioning in accordance with two regimens: 1) lateral, prone, contralateral, supine positions; 2) prone, lateral, contralateral, supine positions. The criterion for changing each position was the change in monitoring indices: SpO2, PaO2, and thoracopulmonary compliance (C).

[An algorithm of respiratory management in the complex treatment and prevention of acute pulmonary lesions in patients with impairments of the central nervous system].

The authors elaborated an algorithm of respiratory management (RM) based on the correlation of RM parameters with the actual and proper thoracopulmonary compliance (C). The algorithm was tested on 42 patients with affections of the central nervous system (CNS) due to severe craniocerebral trauma, spinal trauma, cerebral stroke and multitrauma. Thirty-nine case-matching patients where in the control group--the routine RM algorithm was used for them.

[Cyproterone acetate (Androcur-depo) in the treatment of inoperable prostatic cancer].

The authors consider fundamentals of hormone therapy in prostate cancer, mechanism of long-term androgenic stimulation, detail mechanism of action of antiandrogen (ciproteron acetate-androcur) on the basis of discovered key role of cellular receptor in endocrine regulation of physiological functions in metabolism. Monotherapy with androcur-depo (300 mg once a week) was given to 24 patients with prostatic cancer stage T2-T4. Eight patients had metastases to the bones.