Publications by authors named "M G Carmina"
Background/aims: Myocarditis is an inflammatory disease with diverse clinical presentations. It is known that low-risk patients have a good prognosis compared to high-risk patients. There are few data regarding the prognosis of intermediate-risk patients.
View Article and Find Full Text PDFRetinoid X receptors (RXRs, NR2B1-3) hold therapeutic potential in oncology, neurodegeneration, and metabolic diseases, but traditional RXR agonists mimicking the natural ligand 9- retinoic acid exhibit poor physicochemical properties, pharmacokinetics, and safety profiles. Improved RXR ligands are needed to exploit RXR modulation as a promising therapeutic concept in various indications beyond its current role in second-line cancer treatment. Here, we report the co-crystal structure of RXR in complex with a novel pyrimidine-based ligand and the structure-informed optimization of this scaffold to highly potent and highly soluble RXR agonists.
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- Intravenous drug users (PWIDs) accounted for 9% of the 677 patients with infective endocarditis (IE) studied in an Italian registry, with most being middle-aged males and having significant comorbidities like HIV and chronic liver disease.* -
- The majority of IE cases in PWIDs affected native heart valves, with echocardiographic diagnoses supported by the presence of vegetation in almost 92% of cases, while Staphylococcus aureus was the predominant microorganism isolated.* -
- Surgery was performed on about half of the PWID patients, primarily involving aortic and mitral valves, and those with right-sided IE generally showed a better prognosis and lower need for surgical interventions.*
Background: Myocarditis have variable clinical presentation, evolution and prognosis. Aim of our study was to evaluate the value of speckle tracking echocardiography and cardiac magnetic resonance (CMR) in the short-term prediction of supraventricular arrhythmias (SVA) in patients with acute myocarditis.
Methods: Seventy patients (mean age 31±14 years old) with acute myocarditis and preserved left ventricular ejection fraction (LVEF) were enrolled.
Consensus Document of the Italian Association of Hospital Cardiologists (ANMCO), Italian Society of Pediatric Cardiology (SICP), and Italian Society of Gynaecologists and Obstetrics (SIGO): pregnancy and congenital heart diseases.
Eur Heart J Suppl
May 2017
The success of cardiac surgery over the past 50 years has increased numbers and median age of survivors with congenital heart disease (CHD). Adults now represent two-thirds of patients with CHD; in the USA alone the number is estimated to exceed 1 million. In this population, many affected women reach reproductive age and wish to have children.
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