Publications by authors named "M G Bruzzone"
During out-of-area military operations, the presence of carcinogenic and/or genotoxic agents has been reported, posing potential health risks to deployed soldiers. Military working dogs (MWDs), trained to detect explosives in the same environments as soldiers, could also serve as sentinel animals, providing valuable information on exposure to hazardous agents. These dogs can help identify environmental and potential adverse effects on their health and that of their handlers, possibly before relevant pathologies manifest.
View Article and Find Full Text PDFPurpose: The aim of this study was to evaluate the effectiveness of CDK 4/6 inhibitors (CDK 4-6i) according to HER2 status (low/zero), and endocrine resistance/sensitivity, as well as the efficacy of second-line treatments, in a large real-world cohort.
Methods: The GIM14/BIOMETA study (NCT02284581) is a retrospective/prospective study of the Gruppo Italiano Mammella evaluating treatment patterns and survival outcomes in patients with metastatic breast cancer (MBC). We retrieved data on patients with hormone receptor-positive/HER2-negative MBC receiving first-line CDK 4/6i.
Article Synopsis
- - Membrane contact sites (MCSs) help organelles coordinate activities, but their small size and dynamic nature make them hard to study with traditional imaging methods.
- - Researchers developed chemogenetic reporters that enhance the imaging of MCSs in both lab and living systems, enabling the exploration of complex biological questions.
- - They introduced a new biosensor, PRINCESS, which can detect MCSs and measure calcium dynamics simultaneously, revealing a mechanism where calcium signaling affects the positioning of the endoplasmic reticulum and mitochondria.
Article Synopsis
- * Objectives: The study aimed to see how the size and placement of lesions affect patient outcomes, and to compare two different methods (probabilistic vs. deterministic tractography) for mapping brain pathways involved in tremor control.
- * Results: Using probabilistic tractography provided a more comprehensive view of brain pathways than deterministic methods, and while lesion volume was positively linked to tremor improvement, the overlap with the targeted brain pathway did not show a strong correlation, suggesting that multiple factors contribute to treatment success.
Article Synopsis
- Animals navigate by choosing motor responses based on environmental cues, exemplified by the optokinetic response (OKR) in fruit flies, where visual stimuli affect head movement.
- Research focused on how simultaneous olfactory cues (repellent or masking) influence the OKR in Drosophila melanogaster, providing insights into multimodal integration of sensory information.
- The study reveals that fruit flies are a cost-effective model for investigating how different compounds impact insect navigation, highlighting the effects of substance concentration on their movement dynamics.