Trends in naloxone co-prescriptions.

Background: The opioid epidemic remains a significant public health crisis in the United States. Naloxone has been identified as a critical component in combating this crisis. However, co-prescription rates among patients receiving opioids remain suboptimal, especially among certain high-risk populations.

Longitudinal trajectories of digital upper limb biomarkers for multiple sclerosis.

Background: Upper limb dysfunction is a common debilitating feature of relapsing-remitting multiple sclerosis (RRMS). We aimed to examine the longitudinal trajectory of the iPad®-based Manual Dexterity Test (MDT) and predictors of change over time.

Methods: We prospectively enrolled RRMS patients (limited to Expanded Disability Status Scale (EDSS) < 4).

Universal Teacher-Child Interaction Training in early childhood special education: Identifying mechanisms of action that explain why it works.

Teacher-Child Interaction Training-Universal (TCIT-U) is effective for increasing teachers' use of strategies that promote positive child behavior; however, the exact mechanisms of change are unknown. Using a cluster randomized control trial in a sample of 410 racially- and ethnically-diverse children (M = 41.73 months; 50% White, 45% Black/African-American, 4% Multiracial, 1% Asian; 59% Hispanic; 87% with disabilities) taught by 102 teachers from 38 classrooms in eight schools, we attempted to identify these mechanisms of action.

Does the Type of Cannula Matter? A Case Report and Review of the Evidence Regarding Steel and Plastic Cannulae With Respect to a Continuous Subcutaneous Insulin Infusion.

A new paradigm in the management of diabetes mellitus evolved following the introduction of continuous subcutaneous insulin infusions (CSII) into clinical practice. Outcomes include greater patient satisfaction alongside improved glycemic control. Drawbacks, however, which cannot be omitted, include patient, technology, and both patient and provider error.