Publications by authors named "M G A Sattler"
The molecular mechanisms by which worm parasites evade host immunity are incompletely understood. In a mouse model of intestinal helminth infection using (), we show that helminthic glutamate dehydrogenase (heGDH) drives parasite chronicity by suppressing macrophage-mediated host defense. Combining RNA-seq, ChIP-seq, and targeted lipidomics, we identify prostaglandin E (PGE) as a major immune regulatory mechanism of heGDH.
View Article and Find Full Text PDFRNA-binding proteins are essential for gene regulation and the spatial organization of cells. Here, we report that the yeast ribosome biogenesis factor Loc1p is an intrinsically disordered RNA-binding protein with eight repeating positively charged, unstructured nucleic acid binding (PUN) motifs. While a single of these previously undefined motifs stabilizes folded RNAs, multiple copies strongly cooperate to catalyze RNA folding.
View Article and Find Full Text PDFArticle Synopsis
- Intensity modulated proton therapy (IMPT) faces challenges from patient setup and proton range uncertainties, leading to longer planning times with robust optimization methods.
- A deep learning (DL) model was developed to predict dose distributions in various error scenarios for head and neck cancer patients, effectively evaluating plan robustness.
- The model demonstrated impressive accuracy, aligning closely with ground truth plans for most patients, and was able to predict full 3D dose distributions quickly, making it a viable option for enhancing IMPT treatment planning.
Purpose: Breast cancer (BC) treatment can induce adverse events, such as cardiovascular disease (CVD). Defective DNA repair, as in carriers of BRCA1/2 pathogenic variants (BRCA1/2pv), may contribute to CVD risk. We aimed to study if female BRCA1/2pv carriers are more sensitive to develop CVD after BC treatment than BC patients without a known BRCA1/2pv.
View Article and Find Full Text PDFBackground: The COVID-19 vaccination campaign in several European countries involved collaboration between public health and Primary Health Care (PHC).
Objective: To highlight the role of PHC professionals in the COVID-19 vaccination rollout, specifically in terms of vaccine administration, communication and contributing to vaccination population coverage.
Methods: A descriptive retrospective study of the COVID-19 vaccination campaign across 28 European countries was conducted, covering data from December 2020 to November 2021.