Publications by authors named "M Furuta"
Article Synopsis
- The study examined the prevalence and characteristics of MSI-high tumors in patients with metastatic or recurrent gastric cancer (GC) that had not yet undergone chemotherapy.
- MSI-high GC was found in 5.6% of patients, with higher prevalence in females, individuals aged 70 and older, tumors located in the lower stomach, HER2-negative cases, and patients without liver metastases.
- Understanding these MSI-high tumors can enhance clinical practices and inform future research targeting this specific subtype of GC.
Epithelioid pleural mesothelioma successfully treated with perioperative immunotherapy: a case report.
Gen Thorac Cardiovasc Surg Cases
June 2024
Background: Pleural mesothelioma, characterized by a dismal prognosis even with multimodal therapy, has seen emerging interest in immune checkpoint inhibitors (ICIs) due to their demonstrated efficacy. Here, we present a case of epithelioid-type pleural mesothelioma with chest wall invasion treated with definitive ICI therapy, resulting in a remarkable pretreatment effect.
Case Presentation: A 46-year-old man was diagnosed with an abnormal chest shadow on a medical check, and a computed tomography scan showed pleural thickening at the dorsal right upper chest wall.
Introduction: Oligometastasis and oligoprogression (OP) has not been adequately defined in extensive-stage SCLC (ES-SCLC) and may be a good indication for adding local treatment. Therefore, this multicenter study aimed to investigate the prognostic impact of oligometastasis and OP in ES-SCLC.
Methods: We enrolled patients who received chemoimmunotherapy between September 2019 and June 2022.
Article Synopsis
- The study investigates the effectiveness of durvalumab combined with chemoradiotherapy (CRT) versus CRT alone in treating locoregional recurrence of non-small-cell lung cancer (NSCLC) after complete resection.
- Using propensity score analysis to adjust for confounding variables, the research involved 119 patients in the CRT-D group and 111 in the CRT group, noting differences in gender distribution and adenocarcinoma rates.
- Results indicated that the median progression-free survival was significantly longer in the CRT-D group (25.4 months) compared to the CRT group (11.5 months), suggesting that the combination treatment could be a beneficial strategy for these patients.
Aims: This study investigates the cell physiology of thermally injured bacterial cells, with a specific focus on oxidative stress and the repair mechanisms associated with oxidative secondary stress.
Methods And Results: We explored the effect of heat treatment on the activity of two protective enzymes, levels of intracellular reactive oxygen species, and redox potential. The findings reveal that enzyme activity slightly increased after heat treatment, gradually returning to baseline levels during subculture.