Impaired Spermatogenesis in Infertile Patients with Orchitis and Experimental Autoimmune Orchitis in Rats.

Experimental autoimmune orchitis (EAO) is a well-established rodent model of organ-specific autoimmunity associated with infertility in which the testis immunohistopathology has been extensively studied. In contrast, analysis of testis biopsies from infertile patients associated with inflammation has been more limited. In this work, testicular biopsies from patients with idiopathic non-obstructive azoospermia diagnosed with hypospermatogenesis (HypoSp) [mild: = 9, and severe: = 11], with obstructive azoospermia and complete Sp (spermatogenesis) (control group, C, = 9), and from Sertoli cell-only syndrome (SCOS, = 9) were analyzed for the presence of immune cells, spermatogonia and Sertoli cell (SCs) alterations, and reproductive hormones levels.

Effects of lactic, malic and fumaric acids on spp. counts and on chicken meat quality and sensory characteristics.

The aim of this work was to assess the effectiveness of dipping chicken breast in lactic, malic and fumaric acid 3% solutions for 15 s on counts, as well as on chicken meat quality and sensory characteristics. All three treatments effectively reduced counts. The values of log reduction were 2.

Utilisation of exercise as part of guideline-based care for hip pain in the Australian workers' compensation environment.

Background: Guidelines recommend early referral for exercise for hip pain. It is unclear if this occurs in the Australian workers' compensation environment.

Objective: To investigate referral for exercise in workers with a compensable hip claim.

First custom next-generation sequencing infertility panel in Latin America: design and first results.

Objective: To present the development of the first custom gene panel for the diagnosis of male and female infertility in Latin America.

Methods: We developed a next-generation sequencing (NGS) panel that assesses genes associated with infertility. The panel targeted exons and their flanking regions.

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

In the last decades, inhibitors of histone deacetylases (HDAC) have become an important class of anti-cancer agents. In a previous study we described the synthesis of spiro[chromane-2,4'-piperidine]hydroxamic acid derivatives able to inhibit histone deacetylase enzymes. Herein, we present our exploration for new derivatives by replacing the piperidine moiety with various cycloamines.