Publications by authors named "M Fukayama"
Article Synopsis
- HNF4α expression and SMARCA4 loss in lung adenocarcinomas were studied by analyzing 241 cases, leading to the classification of HNF4α-positive adenocarcinomas into variant and conventional non-mucinous groups based on their histological characteristics and mutation profiles.
- The study identified distinct groups, with variant cases retaining SMARCA4 and being negative for TTF-1, while among conventional non-mucinous cases, the non-TRU-type group frequently exhibited loss of SMARCA4 and had poorer prognosis.
- Overall, the findings suggested that HNF4α-positive adenocarcinomas can show different pathological features and survival outcomes,
Background: DNA methylation accumulates in non-malignant gastric mucosa after exposure to pathogens. To elucidate how environmental, methylation, and lifestyle factors interplay to influence primary gastric neoplasia (GN) risk, we analyzed longitudinally monitored cohorts in Japan and Singapore.
Methods: Asymptomatic subjects who underwent a gastric mucosal biopsy on the health check-up were enrolled.
Article Synopsis
- Gastric cancer risk is linked to chronic gastritis, and the OLGIM system can determine GC risk based on the level of intestinal metaplasia (IM), although scoring requires considerable expertise.
- A deep learning model, ResNet50, was used to analyze 5753 images of gastric biopsy samples, achieving a high sensitivity (97.7%) and specificity (94.6%) in classifying IM.
- The study indicates that the AI system can improve the accuracy and consistency of GC risk evaluation, potentially standardizing pathology assessments globally.
Abnormalities of the AT-rich interaction domain 1A (ARID1A) occur in cancer tissues and precursors or premalignant lesions in various organs. To investigate the significance of ARID1A abnormalities in the early phase of cancer development in the stomach, we screened for ARID1A loss and p53 overexpression in glands in non-neoplastic gastric mucosa using immunohistochemistry. We tested 230 tissue blocks of 77 patients with gastric carcinoma, and in 10% of non-neoplastic mucosa we detected ARID1A-lost and in 3.
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