Dietary RNA from Torula Yeast Prevents Capillary Regression in Atrophied Skeletal Muscle in Rats.

Chronic neuromuscular inactivity induces capillary regression within skeletal muscle. The objective of this study was to investigate the potential effects of dietary nucleic acids in counteracting the capillary reduction linked to chronic neuromuscular inactivity in the soleus muscle. The study utilized four distinct groups of female Wistar rats: a control group (CON), a hindlimb-unloading group (HU), an HU group supplemented with DNA (HU + DNA), and an HU group supplemented with RNA (HU + RNA).

Iron nutrition and COVID-19 among Nigerian healthcare workers.

Background And Objectives: The optimal iron hypothesis (OIH) posits that risk for infection is lowest at a mild level of iron deficiency. The extent to which this protection results from arms race dynamics in the evolution of iron acquisition and sequestration mechanisms is unclear. We evaluated the OIH with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an emerging infectious agent.

MYO18B promotes lysosomal exocytosis by facilitating focal adhesion maturation.

Many cancer cells exhibit increased amounts of paucimannose glycans, which are truncated N-glycan structures rarely found in mammals. Paucimannosidic proteins are proposedly generated within lysosomes and exposed on the cell surface through a yet uncertain mechanism. In this study, we revealed that paucimannosidic proteins are produced by lysosomal glycosidases and secreted via lysosomal exocytosis.

Trideoxycytidine diphosphate promotes neural stem cell proliferation and neurogenesis in mice.

Background: Food-derived nucleic acids exhibit various biological activities and may act as nutrients. Oral ingestion of the nucleic acid fraction (NAF) of salmon milt extract hydrolysates enhances cognitive function in mice although their active ingredients have not yet been identified, and detailed mechanisms of action are unknown.

Objective: To identify active ingredients enhancing cognitive function contained in the NAF and its possible underlying mechanism.

Dynamic CT-perfusion parameters as indicators of microcirculation: investigation in patients without obstructive coronary artery disease.

Aim: To investigate the relationship between each CTP parameter and that between CTP parameters and patient characteristics in patients without obstructive coronary artery disease (CAD).

Materials And Methods: Seventy-seven (28 female; 65.0±10.