Publications by authors named "M Frydrychowicz"
Non-small cell lung cancer (NSCLC) leads as a primary cause of cancer-related premature mortality in Western populations. This study leverages cutting-edge gene-expression-profiling technologies to perform an in-depth molecular characterization of NSCLC specimens, with the objective of uncovering tumor-specific genomic alterations. By employing DNA microarray analysis, our research aims to refine the classification of NSCLC for early detection, guide molecular-targeted treatment approaches, enhance prognostication, and broaden the scientific understanding of the disease's biology.
View Article and Find Full Text PDFThe adaptive response occurs only after 7-10 days of antigen presentation. Nevertheless, the autoreactive T cells infiltrate the stroke lesion within the first 48 h. Thus, we hypothesized that the unconventional lymphocytes as invariant natural killer T cells (iNKT) and γδT cells that share immediate innate and delayed adaptive response features are involved in acute stroke pathophysiology.
View Article and Find Full Text PDFTemporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case-control study.
J Neuroinflammation
November 2023
Article Synopsis
- - Tregs play a dual role in the immune response after ischemic stroke, being both protective and potentially harmful; their function may lead to immunodepression and increased risk of stroke-associated infections (SAI), influenced by the presence of the Helios transcription factor in Tregs.
- - A study measuring Treg populations in stroke patients showed a significant decrease in Helios-positive Tregs (H+ Tregs) over time, with an increase in Helios-negative Tregs (H- Tregs), particularly noted on day 3 post-stroke in patients who developed infections.
- - Despite higher levels of H+ Tregs being linked to SAI and correlation with stroke severity, they were not identified as an independent
Article Synopsis
- C3 glomerulopathies (C3GN) are rare kidney diseases caused by problems with the complement system, leading to C3 accumulation in kidneys; this study analyzed biopsy samples from 332 patients diagnosed with C3GN.
- Among the examined cases, 111 were identified as C3GN, 17 as dense deposit disease (DDD), and the majority (204) were non-classified due to insufficient severity of lesions.
- The findings emphasize the importance of using electron microscopy to assess suspected C3 glomerulopathies, especially in cases where lesions are difficult to detect with other microscopy methods.
Neuroborreliosis is a form of Lyme Borreliosis (LB) that affects various structures of the central and peripheral nervous system. Although most cases of LB can be cured with a course of antibiotics, some children can present prolonged symptoms, which may constitute post-treatment Lyme disease syndrome (PTLDS). The aim of our analysis was the long-term observation of children with NB and the determination of their risk of PTLDS.
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