Publications by authors named "M Fridman"
Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a higher mortality rate. New prospects of OC diagnosis and treatment have been opened in studies of the gene regulation mechanisms that involve long noncoding RNAs (lncRNAs) and identification of the lncRNA genes that are inhibited via methylation of the promoter region. A set of 122 samples of primary OC tumors was examined by methylation specific real-time PCR to assess the methylation level of the lncRNA genes PLUT, SNHG1, SNHG6, SNHG12, and TINCR.
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- The small nucleolar RNA host gene (SNHG) family may contribute to cancer development by creating long non-coding RNAs and affecting ribosome production and small nucleolar RNA formation.
- A study analyzing 122 ovarian cancer samples found significant increases in the methylation levels of five SNHG family lncRNA genes, linking these changes to factors like tumor progression and metastasis.
- Additionally, there was a notable co-methylation among four of these genes and predictions of their interactions with specific microRNAs, suggesting their collective role in ovarian cancer pathogenesis.
Our work aimed to evaluate and differentiate the role of ten lncRNA genes (, , , , , , , , , and ) in the development and progression of epithelial ovarian cancer (EOC). A representative set of clinical samples was used: 140 primary tumors from patients without and with metastases and 59 peritoneal metastases. Using MS-qPCR, we demonstrated an increase in methylation levels of all ten lncRNA genes in tumors compared to normal tissues ( < 0.
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- Finding the global minimum in complex networks is tough, especially in human networks that must adapt to various disturbances like conflicts and climate change.
- Our study on violin players showed that human networks use unique methods, like changing coupling strength and tempo, to avoid local minima, making them more resilient than non-human networks.
- The research highlights phenomena like high-order vortex states and oscillation death, and it may inform various fields such as politics, economics, and AI-driven decision-making.
Chemiluminescence is the emission of light that occurs as a result of a chemical reaction. Depending on the rate of chemiexcitation, light emission can occur as a long-lasting, low-intensity, glow-type reaction or a rapid, highly intense flash-type reaction. Assays using a flash-type mode of action provide enhanced detection sensitivity compared to those using a glow-type mode.
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