Publications by authors named "M Fredi"
Fetal-hope study: Home monitoring of fetal heart rate in SSA + pregnant women: Rationale and design.
Eur J Obstet Gynecol Reprod Biol
December 2024
Article Synopsis
- About 0.5-1% of women of childbearing age have anti-Ro/SSA and anti-La/SSB antibodies, potentially leading to Neonatal Lupus, primarily manifesting as complete heart block (AVB) in fetuses.
- The study aims to assess the effectiveness of home monitoring of fetal heart rates using a handheld device in pregnant women with these antibodies and to see if early treatment can help.
- Currently, patients are being recruited across 11 Italian centers for a prospective observational study, with regular monitoring and check-ups to track maternal and fetal health outcomes.
Article Synopsis
- * A total of 69 patients were analyzed, showing high concordance for certain antibodies (like anti-Ku and anti-PM/Scl) and moderate agreement for others (like anti-Jo1 and anti-Mi-2), while some antibodies could only be detected by one method.
- * The results suggest that LB may be more sensitive for detecting multiple MSAs and specific antibodies, while IP performs well for dermatomyositis-associated MSAs
Background: The incidence of skin cancer in patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) has only been investigated with retrospective studies enrolling a low number of patients. The aims of our study were to assess the incidence of skin cancer in two large cohorts of patients, one with SLE and the other with SSc and investigating possible risk factors.
Methods: Ninety SLE, 53 SSc patients and 392 control subjects were enrolled.
Article Synopsis
- The study examined pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) enrolled in the Italian P-RHEUM.it cohort from 2018 to 2023, focusing on maternal and infant health.
- Results showed that out of 866 pregnancies, 15.6% experienced maternal disease flares, 30.1% had obstetrical complications, and 91.7% resulted in live births, with a relatively low rate of perinatal deaths and complications.
- The research concluded that effective preconception counseling and proper medication management during pregnancy may help reduce disease-related risks, suggesting that outcomes for women with ARD were comparable to those in the general obstetric population.