Publications by authors named "M Franciosi"
Article Synopsis
- Cervical cancer is the fourth most common cancer globally, and its tumor microenvironment features various cytokines and purinergic signaling that influence disease progression.
- The review examines the immunological mechanisms and purinergic pathways in cervical cancer to identify potential therapeutic targets.
- Key pro-inflammatory cytokines include IL-17, IL-1β, IL-6, and IL-18, while blocking receptors like P2X7 and A2A could offer new treatment strategies to enhance immune response against tumors.
The coronavirus disease (COVID-19), caused by SARS-CoV-2 infection, accounts for more than 2.4 million deaths worldwide, making it the main public health problem in 2020. Purinergic signaling is involved in the pathophysiology of several viral infections which makes the purinergic system a potential target of investigation in COVID-19.
View Article and Find Full Text PDFCervical cancer is the fourth most common type of cancer incidence in the world female population, and it has become a public health problem worldwide. Several factors are involved in this type of cancer, including intrinsic factors related to the inflammatory process, such as extracellular nucleotides and adenosine-components of the purinergic system. The present review focuses on the role of the purinergic system in cervical cancer, especially regarding the interaction of extracellular nucleotides with their respective receptors expressed in the tumor microenvironment of cervical cancer and their role in the host immune response.
View Article and Find Full Text PDFAims/hypothesis: Diabetes treatments were related with either an increased or reduced risk of cancer. There is ongoing debate about a potential protective action of metformin. To summarize evidence on the association between metformin and risk of cancer and cancer mortality in patients with diabetes.
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