Publications by authors named "M Franchina"
Article Synopsis
- - Autophagy is a vital cellular process that helps keep cells healthy by breaking down damaged proteins and organelles, especially during stress, and it's essential in maintaining the endometrium and supporting pregnancy.
- - This process is regulated by various signaling pathways and plays a complex role in preventing tumors by managing cellular homeostasis, but can also promote cancer progression in endometrial carcinoma by supporting nutrient supply for cancer cells.
- - Investigating autophagy's mechanisms and pathways reveals its potential as a therapeutic target in treating endometrial carcinoma, offering hope for effective treatments and overcoming resistance to existing therapies.
Beyond the gluten-free diet: Innovations in celiac disease therapeutics.
World J Gastroenterol
October 2024
Article Synopsis
- * The only current treatment is a strict lifelong gluten-free diet, but adherence can be tough, boosting research into alternative therapies like enzymatic gluten breakdown and immune modulation.
- * New pharmacologic strategies, including transglutaminase inhibitors and nanoparticle therapies, aim to improve patient outcomes and quality of life by shifting treatment from dietary restrictions to more flexible options.
Article Synopsis
- Thyroid nodules are commonly benign growths that occur more in women and those with iodine deficiency or prior radiation exposure.
- Treatment for these nodules includes medications, surgery, and thermal ablation (TA), a method using heat to destroy tissue.
- This study investigates changes in tissue from thyroid nodules treated with TA and aims to differentiate between benign and malignant nodules using advanced techniques like immunohistochemistry.
Bladder cancer is a prevalent urinary system malignancy and urinary cytology is widely used for its screening and follow-up. A novel diagnostic tool called Bladder Epicheck (BE) is increasingly being used for monitoring the recurrence of non-muscle-invasive bladder cancer (NMIBC). The simultaneous use of BE and urinary cytology can increase the diagnostic performances in the follow-up of bladder neoplasms.
View Article and Find Full Text PDFAmong autophagic-related proteins, p62/SQSTM1/Sequestosome-1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplastic diseases, no available information have been reported in meningiomas, which have an high epidemiological relevance being the second most common category of intracranial tumors after gliomas. Generally meningiomas have a benign behavior, but their recurrence is not uncommon mainly when atypical or anaplastic varieties occur.
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