Publications by authors named "M Fragoso"
Context: The role of plasma metanephrine in adrenal venous sampling (AVS) for assessing lateralization in primary aldosteronism (PA) requires further clarification.
Objective: To evaluate the performance of plasma metanephrine in AVS for determining aldosterone lateralization in PA, with or without mild autonomous cortisol secretion (MACS).
Methods: Sequential AVS under cosyntropin stimulation was conducted in 58 consecutive patients with PA and indication for AVS.
Objective: Germline and somatic drivers are identified in 30% and 40% of pheochromocytomas and paragangliomas (PPGLs), respectively. In this study, we investigated the genetic landscape of PPGLs in a Brazilian cohort.
Methods: We studied 182 index patients with PPGLs (116 females and 66 males), comprising 118 pheochromocytoma and 70 paraganglioma cases.
Open ventral hernia repair is one of the most commonly performed surgeries by general surgeons worldwide. In the case of complex incisional hernias, there are adjunct techniques that can help abdominal wall reconstruction surgery, such as type A botulinum toxin (BTA), whose injection results in muscle relaxation and growth of muscle fiber length, allowing fascial closure without the need for advanced techniques. We report a case of a male patient who underwent ultrasound-guided BTA injection in the abdominal wall and, five days later, was admitted to our emergency department with dysarthria, muscular weakness, dyspnea on small exertion, and constipation.
View Article and Find Full Text PDFBackground: Aldosterone excess chronically induces oxidative stress and cell proliferation. Previously, a single study investigated primary aldosteronism (PA) in patients with papillary thyroid cancer (PTC), albeit without a matched control group.
Methods: We conducted a propensity score matched case-control study to investigate the association between PA and PTC in individuals with arterial hypertension (HT).
Article Synopsis
- The recreational use of nitrous oxide (NO) has risen recently, leading to more reported cases of toxicity, particularly neurological disorders like subacute combined degeneration (SCD) and polyneuropathy due to vitamin B deficiency.
- Two patients misusing NO exhibited symptoms resembling Guillain-Barré Syndrome (GBS), with MRI findings of transverse myelitis and evidence of mixed polyneuropathy, indicating myeloneuropathy linked to vitamin B deficiency.
- Symptoms improved with vitamin B treatment and stopping NO, highlighting the need for awareness of NO's neurotoxic effects, especially as its use increases.