Root and Eruption Defects in c-Fos Mice Are Driven by Loss of Osteoclasts.

c-Fos homozygous mice lack osteoclasts with a failure of the teeth to erupt and with an arrest of root development. Here, we characterize the defects associated with the failure in root development and the loss of the tooth-bone interface, and we investigate the underlying causes. We show that, while homozygous c-Fos mice have no multinucleated osteoclasts, heterozygous mice have a reduction in the number of osteoclasts with a reduction in the tooth-bone interface during development and subtle skeletal defects postnatally.

Antibacterial activity of peptides homologous to a loop region in human lactoferrin.

Human lactoferrin contains a 46 residue sequence named lactoferricin H thought to be responsible for its antimicrobial properties. Synthetic peptides HLT1, corresponding to the loop region of human lactoferricin (FQWQR-NMRKVRGPPVS) and HLT2, corresponding to its charged portion (FQWQRNMRKVR), exerted significant antibacterial effects against E. coli serotype O111 strains NCTC 8007 and ML35.

Dynamization timing and its effect on bone healing when using the Orthofix Dynamic Axial Fixator.

We report the effect of dynamization timing on healing rates when treating tibial fractures with the Dynamic Axial Factor (Orthofix, registered trademark). Sixty-nine patients with 71 fresh tibial fractures were grouped retrospectively for age, Gustilo and Anderson wound grading, site of tibial fracture and presence of an intact fibula or stable fibular fracture. Pairs were then generated chronologically to compare healing rates in those patients dynamized before 4 weeks with those dynamized after this time.