Background: Air pollution is the leading environmental risk factor for health. Assessing outdoor air pollution exposure with detailed spatial and temporal variability in urban areas is crucial for evaluating its health effects.
Aim: We developed and compared Land Use Regression (LUR), dispersion (DM), and hybrid (HM) models to estimate outdoor concentrations for NO, PM, black carbon (BC), and PM (Fe, Cu, Zn) in Barcelona.
Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains: the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic).
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