Publications by authors named "M Foley"
Background And Objectives: Despite effective secondary prevention, including oral anticoagulant (OAC) therapy, the risk of recurrent stroke (RS) in patients with atrial fibrillation (AF) remains substantial with an annualized risk of 3.2%-6.5% per year.
View Article and Find Full Text PDFKidney fibrosis is the common pathological pathway in progressive chronic kidney disease (CKD), and current treatments are largely ineffective. The C-X-C chemokine receptor 4 (CXCR4) is crucial to fibrosis development. By using neural cell adhesion molecules as scaffolds with binding loops that mimic the shape of shark antibodies, fully humanized single-domain i-bodies have been developed.
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- Medication adjustments for Parkinson's disease are based on patient feedback and clinicians' assessments of motor symptoms like bradykinesia and tremor.
- This study evaluates how consistently different clinicians assess upper limb motor function in Parkinson's patients during video recordings of standardized hand movements.
- Results show that initial agreement among clinicians was poor, especially for certain movements, but training improved their consistency in ratings significantly.
Article Synopsis
- The ORBITA-2 trial examined the effectiveness of percutaneous coronary intervention (PCI) in relieving stable angina in patients with coronary artery disease (CAD) compared to a placebo.
- Participants reported daily angina episodes and underwent tests to measure fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) before being randomized to receive either PCI or a placebo.
- Results indicated that lower FFR and iFR values were associated with significantly greater improvement in angina symptoms following PCI, suggesting these measurements can help predict the benefits of the intervention.
Iron (Fe) is a trace nutrient required by nearly all organisms. As a result of the demand for Fe and the toxicity of non-chelated cytosolic ionic Fe, regulatory systems have evolved to tightly balance Fe acquisition and usage while limiting overload. In most bacteria, including the mammalian pathogen , the ferric uptake regulator (Fur) is the primary transcriptional regulator controlling the transcription of genes that code for Fe uptake and utilization proteins.
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