Publications by authors named "M Floris-Moore"
Background: Integrase strand transfer inhibitors (INSTIs) and the menopausal transition have separately been associated with body composition changes in women with HIV (WWH), but their interaction is unknown.
Methods: From 2006-2019, 1131 non-pregnant WWH with viral suppression [(419 who switched to INSTI (INSTI+); 712 who did not switch (INSTI-)] and 887 women without HIV (WWOH) from the Women's Interagency HIV Study were included. Mixed effect models were used to evaluate change in waist circumference (WC) and BMI by menopausal phase defined using anti-Müllerian hormone, a biomarker of ovarian reserve.
Article Synopsis
- The study aimed to explore the health outcomes of women with HIV who have low-level viremia (LLV), focusing on virologic failure and the development of non-AIDS comorbidities.
- Researchers analyzed data from the Women's Interagency HIV Study, categorizing women based on their viral load status into groups: virologic suppression, intermittent LLV, persistent LLV, and virologic failure.
- Results indicated that women with intermittent or persistent LLV had a higher risk of virologic failure compared to those with virologic suppression, with persistent LLV showing a tendency towards increased risk for multiple health issues.
Objective: Diabetes mellitus (DM) is associated with lower antiretroviral (ART) drug exposure among persons with HIV (PWH) compared to PWH without DM. The association between DM and virologic control in PWH, however, remains unknown.
Methods: We included participants in the Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort Study (MWCCS) who had initiated ART between 1999 and 2020 and had a suppressed HIV viral load (≤200 copies/ml) within 1 year of ART initiation.
Article Synopsis
- Host metabolic issues, particularly in tryptophan metabolism, are linked to the severity of COVID-19 and long COVID symptoms.
- People with HIV also experience similar metabolic problems, raising questions about their risk for severe COVID-19 outcomes.
- Research on samples from people living with HIV indicates that certain metabolic changes may predict higher risks for severe COVID-19 and long COVID, suggesting a need for further study.
Hepatitis C virus (HCV) infection is associated with extrahepatic effects, including reduced diffusing capacity of the lungs. It is unknown whether clearance of HCV infection is associated with improved diffusing capacity. In this sample of women with and without human immunodeficiency virus, there was no association between HCV clearance and diffusing capacity.
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