The Fifth Annual Symposium of the Midwest Aging Consortium.

As the healthcare burden caused by an increasingly aging population rapidly rises, a pressing need exists for innovative geroscience research that can elucidate aging mechanisms and precipitate the development of therapeutic interventions to support healthy aging. The Fifth Annual Midwest Aging Consortium Aging Research symposium, held from April 28-30, 2024, was hosted by The Ohio State University in Columbus, Ohio and featured presentations from investigators across the Midwestern United States. This report summarizes the research presented at the symposium, whose topics included cellular senescence and the aging brain, metabolism and metabolic interventions, nutrition, redox mechanisms and biomarkers, and stress mechanisms.

Cardiac matrix-bound Nanovesicles provide insight into mechanisms of clinical heart disease progression to failure.

Aims: Remodeling of the extracellular matrix (ECM) is critical for effective wound healing and maintaining organ homeostasis. The ECM of soft tissues, including cardiac, contains embedded nanovesicles; or matrix-bound nanovesicles (MBV). The luminal cargo of MBV consists of lipids, microRNAs (miRNAs), and proteins that influence the function of immune and stromal cells.

Multigenerational Rearing on Non-Prey Foods Does Not Affect Prey (Aphid) Recognition Behavior of (Coleoptera: Coccinellidae).

The pink spotted lady beetle has been identified as a promising predator to mass rear and release into greenhouses and high tunnels to control aphids on small fruits and vegetables. This study tested the hypothesis that laboratory-reared . , without any exposure to aphids for multiple generations, could recognize, attack, and consume live aphids.

Evaluating Tenebrio molitor (Coleoptera: Tenebrionidae) for the reduction of fumonisin B1 levels in livestock feed.

The yellow mealworm, Tenebrio molitor, L., can be an important component of the circular economy because of its ability to transform a variety of agricultural wastes and byproducts into valuable livestock feed. Analysis of their ability to endure toxins coupled with their potential to transfer contaminants to higher trophic levels is not complete.