MIMO ultra-local model-based adaptive enhanced model-free control using extremum-seeking for coupled mechatronic systems.

Multiple degree-of-freedom (DOF) mechatronic systems, such as robots and robotic arms, play a crucial role in modern life and production. However, due to strong coupling, uncertain dynamics, and external disturbance, accurately modeling these systems is challenging, making traditional model-based control methods impractical. To address this, this paper proposes an extremum-seeking-based adaptive enhanced model-free control for multi-input multi-output (MIMO) mechatronic systems to realize robust trajectory tracking.

Feedback control of social distancing for COVID-19 via elementary formulae.

Social distancing has been enacted in order to mitigate the spread of COVID-19. Like many authors, we adopt the classic epidemic SIR model, where the infection rate is the control variable. Its differential flatness property yields elementary closed-form formulae for open-loop social distancing scenarios, where, for instance, the increase of the number of uninfected people may be taken into account.

Nephila edulis-breeding and care under laboratory conditions.

Due to fascinating mechanical and biological characteristics spider silk is of great interest in many research fields. Among the orb-weavers Nephila edulis is one of the species used as source for natural spider silk in laboratories. Under appropriate conditions, animals can be kept and bred easily.

In vitro enhancement and functional characterization of neurite outgrowth by undifferentiated adipose-derived stem cells.

Adipose‑derived stem cells (ASCs) can easily be obtained and expanded in vitro for use in autologous cell therapy. Via their production of cytokines and neurotrophic factors, transplanted ASCs provide neuroprotection, neovascularization and induction of axonal sprouting. However, the influencing mechanism of undifferentiated ASCs on nerve regeneration is currently only partially understood.

Toward a model-free feedback control synthesis for treating acute inflammation.

An effective and patient-specific feedback control synthesis for inflammation resolution is still an ongoing research area. A strategy consisting of manipulating a pro and anti-inflammatory mediator is considered here as used in some promising model-based control studies. These earlier studies, unfortunately, suffer from the difficultly of calibration due to the heterogeneity of individual patient responses even under similar initial conditions.