Neurodevelopmental evolution of West syndrome: a 2-year prospective study.

Objective: The aim of this study was to evaluate the epileptic and developmental evolution in infants with West syndrome.

Methods: A prospective study of 21 infants was performed, with a follow-up at 2 years. Serial assessment included long-term EEG monitoring, visual and auditory evaluation and assessment of neurodevelopment.

Maturation of cerebral electrical activity and development of cortical folding in young very preterm infants.

Objective: The aim of this study was to examine the relationship between cortical development and cerebral electrical activity at early gestational ages.

Methods: We obtained EEGs (7.2+/-3.

Auditory attention at the onset of West syndrome: correlation with EEG patterns and visual function.

At the onset of West syndrome a specific impairment of visual function has been clearly demonstrated, while other aspects of sensorial development, and in particular of the auditory function, have been less studied. The aim of this study was to evaluate auditory function and orienting responses at the onset of West syndrome, and to relate the results with EEG patterns, visual function and neurodevelopmental competence. A prospective multicentric study was performed on 25 successively enrolled infants with West syndrome; all the patients underwent a full clinical assessment, including MRI and video-EEG, visual function and auditory orienting responses (AORs) as well as Griffiths' developmental scales.

Prognostic value of EEG performed at term age in preterm infants.

Rationale: Electroencephalography (EEG) was performed at term age on 32 infants born prematurely (25-32 weeks). EEG was assessed looking for overall background activity and transients.

Methods: A quantitative analysis was performed, selecting 5-min epochs of "tracé alternant" free of artefacts during quiet sleep.

Visual function in infants with West syndrome: correlation with EEG patterns.

Purpose: Several studies have reported behavioral and electrophysiological evidence of visual impairment during the active stage of West syndrome. The underlying mechanisms are, however, poorly understood, and little has been reported about the correlation between visual impairment, EEG patterns, and brain lesions. The aim of the study was to assess visual function at the onset of spasm and 2 months thereafter and relate visual findings to brain lesions and EEG features.